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Tbio
GTPBP1
GTP-binding protein 1

Protein Summary
Description
Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216044
  • ENSP00000216044
  • ENSG00000100226

Symbol
  • GP1
  • GP-1
  • HSPC018
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
virus perturbation
0.98
molecular function
0.94
protein domain
0.85
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.5   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.5   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
55.1
apolipoprotein A 1 measurement
1
1
1
18.4
grip strength measurement
1
1
1
16.8
mean reticulocyte volume
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
55.1
apolipoprotein A 1 measurement
1
18.4
grip strength measurement
1
16.8
mean reticulocyte volume
1
7.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 1
VGNC:12880
458836
Macaque
GTP binding protein 1
701651
Mouse
MGI:109443
14904
Rat
RGD:1306758
300077
Dog
GTP binding protein 1
VGNC:41557
474506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 1
Macaque
GTP binding protein 1
Mouse
Rat
Dog
GTP binding protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00178-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (73)
1 – 10 of 73
CORO1C
Tbio
Novelty: 0.02068813
p_int: 0.999899464
p_ni: 0.000100536
Score: 0.282
Data Source: BioPlex,STRINGDB
RAB27A
Tchem
Family: Enzyme
Novelty: 0.00369416
p_int: 0.989494901
p_ni: 0.010505099
Data Source: BioPlex
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.978837719
p_ni: 0.021162281
Data Source: BioPlex
LOX
Tbio
Family: Enzyme
Novelty: 0.000273
p_int: 0.919018105
p_ni: 0.080981895
Data Source: BioPlex
VASP
Tbio
Novelty: 0.00041984
p_int: 0.844017576
p_ni: 0.155982424
Score: 0.221
Data Source: BioPlex,STRINGDB
RAB17
Tbio
Family: Enzyme
Novelty: 0.04352198
p_int: 0.83027605
p_ni: 0.16972395
Score: 0.345
Data Source: BioPlex,STRINGDB
ISOC2
Tbio
Family: Enzyme
Novelty: 0.33841868
p_int: 0.805606175
p_ni: 0.194393825
Score: 0.188
Data Source: BioPlex,STRINGDB
GP2
Tbio
Novelty: 0.00126542
Score: 0.931
Data Source: STRINGDB
EXOSC4
Tbio
Family: Enzyme
Novelty: 0.00798796
Score: 0.817
Data Source: STRINGDB
CD36
Tbio
Novelty: 0.00140825
Score: 0.812
Data Source: STRINGDB
Publication Statistics
PubMed Score  654.50

PubMed score by year
PubTator Score  234.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer