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Tbio
TCN2
Transcobalamin-2

Protein Summary
Description
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215838
  • ENSP00000215838
  • ENSG00000185339
  • ENST00000407817
  • ENSP00000384914

Symbol
  • TC2
  • II
  • TC
  • TC2
  • TC-2
  • TCII
  • TC II
  • D22S676
  • D22S750
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.83
transcription factor perturbation
0.8
histone modification site profile
0.78
disease
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 483.66   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 483.66   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Nephroblastoma
1
1
0
2
72
Moyamoya disease
1
1
0
1.9
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Nephroblastoma
0
2
72
Moyamoya disease
0
1.9
47.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcobalamin 2
VGNC:6160
470178
Macaque
transcobalamin 2
716085
Mouse
MGI:98534
21452
Rat
RGD:620681
64365
Dog
transcobalamin 2
VGNC:47205
486355
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcobalamin 2
Macaque
transcobalamin 2
Mouse
Rat
Dog
transcobalamin 2
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20062-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Defective CD320 causes methylmalonic aciduria
Reactome
Defective TCN2 causes hereditary megaloblastic anemia
Reactome
Defects in cobalamin (B12) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Name
Explore in Pharos
Explore in Source
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective CD320 causes methylmalonic aciduria
Defective TCN2 causes hereditary megaloblastic anemia
Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (61)
1 – 10 of 61
CD320
Tbio
Novelty: 0.01978884
Score: 0.994
Data Source: Reactome,STRINGDB
MTR
Tbio
Family: Enzyme
Novelty: 0.0006987
Score: 0.806
Data Source: STRINGDB
MTRR
Tbio
Family: Enzyme
Novelty: 0.00231914
Score: 0.79
Data Source: STRINGDB
MTHFR
Tbio
Family: Enzyme
Novelty: 0.00018162
Score: 0.739
Data Source: STRINGDB
SLC19A1
Tchem
Family: Transporter
Novelty: 0.00536763
Score: 0.708
Data Source: STRINGDB
BHMT
Tchem
Family: Enzyme
Novelty: 0.00453508
Score: 0.69
Data Source: STRINGDB
MTHFD1
Tbio
Family: Enzyme
Novelty: 0.0071938
Score: 0.675
Data Source: STRINGDB
CUBN
Tbio
Novelty: 0.00441944
Score: 0.671
Data Source: STRINGDB
BHMT2
Tchem
Family: Enzyme
Novelty: 0.07713739
Score: 0.663
Data Source: STRINGDB
MMADHC
Tbio
Novelty: 0.02299238
Score: 0.653
Data Source: STRINGDB
Publication Statistics
PubMed Score  483.66

PubMed score by year
PubTator Score  388.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer