Tbio APOH Beta-2-glycoprotein 1

Protein Summary

Description

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02749
• B2R9M3
• Q9UCN7

Gene Name

• APOH

Ensembl ID

• ENST00000205948
• ENSP00000205948
• ENSG00000091583

Symbol

• B2G1
• BG
• B2G1
• B2GP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.94
biological process	0.8
disease	0.69
molecular function	0.63
cell line	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2173.66   (req: < 5)

Gene RIFs: 180   (req: <= 3)

Antibodies: 502   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2173.66   (req: >= 5)

Gene RIFs: 180   (req: > 3)

Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0