Tbio APOH Beta-2-glycoprotein 1

Protein Summary

Description

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02749
• B2R9M3
• Q9UCN7

Gene Name

• APOH

Ensembl ID

• ENST00000205948
• ENSP00000205948
• ENSG00000091583

Symbol

• B2G1
• BG
• B2G1
• B2GP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.94
biological process	0.8
disease	0.69
molecular function	0.63
cell line	0.59

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1690.46   (req: < 5)

Gene RIFs: 167   (req: <= 3)

Antibodies: 502   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1690.46   (req: >= 5)

Gene RIFs: 167   (req: > 3)

Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (7)

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (5)

Reactome (4)

KEGG (1)

Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Reactome	Platelet degranulation	128 targets	R-HSA-114608
Reactome	Response to elevated platelet cytosolic Ca2+	133 targets	R-HSA-76005

Name	Explore in Pharos	Explore in Source
Hemostasis	666 targets	R-HSA-109582
Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Platelet degranulation	128 targets	R-HSA-114608
Response to elevated platelet cytosolic Ca2+	133 targets	R-HSA-76005

Gene Ontology Terms (29)

Functions (5)

Components (9)

Processes (15)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
lipid binding	Inferred from Direct Assay (IDA)	BHF-UCL
lipoprotein lipase activator activity	Inferred from Direct Assay (IDA)	BHF-UCL
phospholipid binding	Inferred from Direct Assay (IDA)	BHF-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
heparin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (139)

Explore Interacting Targets

1 – 10 of 139

• See Interactions on String-DB

FLNA

Tbio

Novelty: 0.00038205

p_int: 0.921516266

p_ni: 0.078483734

Score: 0.485

Data Source: BioPlex,STRINGDB

APOA1

Tbio

Novelty: 0.0001431

Score: 0.981

Data Source: STRINGDB

APOC3

Tclin

Novelty: 0.00116356

Score: 0.978

Data Source: STRINGDB

APOB

Tchem

Novelty: 0.00010107

Score: 0.973

Data Source: STRINGDB

AHSG

Tbio

Novelty: 0.00097441

Score: 0.97

Data Source: STRINGDB

APOA2

Tbio

Novelty: 0.00133324

Score: 0.97

Data Source: STRINGDB

F2

Tclin

Family: Enzyme

Novelty: 0.00006072

Score: 0.962

Data Source: STRINGDB

ITIH3

Tbio

Novelty: 0.05958095

Score: 0.956

Data Source: STRINGDB

AMBP

Tbio

Novelty: 0.00235331

Score: 0.954

Data Source: STRINGDB

ITIH4

Tbio

Novelty: 0.00040286

Score: 0.949

Data Source: STRINGDB

Publication Statistics

PubMed Score  1690.46

PubMed score by year

Reset Zoom

PubTator Score  1331.38

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTG

1-70

LWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPI

70-140

ICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSR

140-210

PDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERV

210-280

KIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC

280-345

MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC

Find similar targets by:

Uniprot Keyword

3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Heparin-binding
Polymorphism
Reference proteome
Repeat
Secreted