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Tbio
EFNB1
Ephrin-B1

Protein Summary
Description
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000204961
  • ENSP00000204961
  • ENSG00000090776

Symbol
  • EFL3
  • EPLG2
  • LERK2
  • CFND
  • CFNS
  • EFB1
  • EFL3
  • EPLG2
  • Elk-L
  • LERK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.85
kinase perturbation
0.76
cell type or tissue
0.71
disease
0.65
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.9   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 517   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.9   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
62.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
62.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ephrin B1
694149
Mouse
MGI:102708
13641
Rat
RGD:2540
25186
Dog
ephrin B1
VGNC:40228
607410
Horse
ephrin B1 [Source:HGNC Symbol;Acc:HGNC:3226]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ephrin B1
Mouse
Rat
Dog
ephrin B1
Horse
ephrin B1 [Source:HGNC Symbol;Acc:HGNC:3226]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P98172-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (78)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Reactome
Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Ephrin signaling
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (210)
1 – 10 of 210
EFNB2
Tbio
Novelty: 0.00255095
p_int: 0.999999671
p_ni: 4.2e-8
p_wrong: 2.88e-7
Score: 0.929
Data Source: BioPlex,Reactome,STRINGDB
RGS3
Tbio
Novelty: 0.01749541
p_int: 0.999385774
p_ni: 0.000614164
p_wrong: 6.2e-8
Score: 0.962
Data Source: BioPlex,STRINGDB
PLAC9
Tdark
Novelty: 0.23764669
p_int: 0.997881668
p_ni: 0.002118329
p_wrong: 3e-9
Data Source: BioPlex
ATP1B3
Tclin
Family: Transporter
Novelty: 0.06773518
p_int: 0.996284722
p_ni: 0.003715277
p_wrong: 1e-9
Data Source: BioPlex
HLA-DQA1
Tbio
Novelty: 0.00077488
p_int: 0.992083573
p_ni: 0.007916426
p_wrong: 1e-9
Data Source: BioPlex
DNM2
Tchem
Novelty: 0.00265965
p_int: 0.975365374
p_ni: 0.024626092
p_wrong: 0.000008534
Score: 0.16
Data Source: BioPlex,STRINGDB
PICK1
Tbio
Novelty: 0.0058265
p_int: 0.96889733
p_ni: 0.031102383
p_wrong: 2.87e-7
Score: 0.542
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.956219374
p_ni: 0.043772021
p_wrong: 0.000008604
Data Source: BioPlex
PCDH12
Tbio
Novelty: 0.06268895
p_int: 0.955815241
p_ni: 0.044184758
p_wrong: 1e-9
Score: 0.16
Data Source: BioPlex,STRINGDB
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.95244205
p_ni: 0.047557901
p_wrong: 4.9e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  213.90

PubMed score by year
PubTator Score  124.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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