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Tbio
THPO
Thrombopoietin

Protein Classes
Protein Summary
Description
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000204615
  • ENSP00000204615
  • ENSG00000090534
  • ENST00000445696
  • ENSP00000410763
  • ENST00000647395
  • ENSP00000494504

Symbol
  • MGDF
  • ML
  • TPO
  • MGDF
  • MKCSF
  • MPLLG
  • THCYT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
biological term
0.77
protein domain
0.73
co-expressed gene
0.69
tissue sample
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1869.65   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 553   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1869.65   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 553   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
6
10
93.7
hematological measurement
1
1
1
87.6
platelet crit
2
6
9
78.7
sex hormone-binding globulin measurement
1
1
1
61.7
mean corpuscular volume
1
1
1
15.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
10
93.7
hematological measurement
1
87.6
platelet crit
9
78.7
sex hormone-binding globulin measurement
1
61.7
mean corpuscular volume
1
15.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
thrombopoietin
100428640
Mouse
MGI:101875
21832
Rat
RGD:11455920
108348162
Dog
thrombopoietin
VGNC:54263
100855822
Horse
thrombopoietin
VGNC:24089
100059159
Species
Name
OMA
EggNOG
Inparanoid
Macaque
thrombopoietin
Mouse
Rat
Dog
thrombopoietin
Horse
thrombopoietin
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P40225-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet Aggregation (Plug Formation)
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet Aggregation (Plug Formation)
Platelet activation, signaling and aggregation
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (142)
1 – 10 of 142
MPL
Tclin
Novelty: 0.00146559
Score: 0.996
Data Source: Reactome,STRINGDB
EPO
Tbio
Novelty: 0.00013701
Score: 0.966
Data Source: STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.965
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.96
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.957
Data Source: STRINGDB
CSF3
Tbio
Novelty: 0.00011283
Score: 0.956
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.944
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.932
Data Source: STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.929
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  1869.65

PubMed score by year
PubTator Score  949.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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