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Tbio
PPP1R15A
Protein phosphatase 1 regulatory subunit 15A

Protein Summary
Description
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000200453
  • ENSP00000200453
  • ENSG00000087074

Symbol
  • GADD34
  • GADD34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.95
biological process
0.91
transcription factor binding site profile
0.88
virus perturbation
0.88
gene perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.22   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.22   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
5
92
mean corpuscular hemoglobin concentration
1
1
1
66.9
reticulocyte measurement
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
92
mean corpuscular hemoglobin concentration
1
66.9
reticulocyte measurement
1
52.4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Downregulation of TGF-beta receptor signaling (R-HSA-2173788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Signal Transduction
Reactome
Signaling by TGF-beta Receptor Complex
Reactome
Signaling by TGF-beta family members
Reactome
TGF-beta receptor signaling activates SMADs
Name
Explore in Pharos
Explore in Source
Downregulation of TGF-beta receptor signaling
Signal Transduction
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta family members
TGF-beta receptor signaling activates SMADs
Protein-Protein Interactions (147)
1 – 10 of 147
PLEKHA1
Tbio
Novelty: 0.03634462
p_int: 0.999997674
p_ni: 0.000002323
p_wrong: 3e-9
Score: 0.309
Data Source: BioPlex,STRINGDB
MINK1
Tchem
Family: Kinase
Novelty: 0.00505208
p_int: 0.999945172
p_ni: 0.000054782
p_wrong: 4.6e-8
Score: 0.374
Data Source: BioPlex,STRINGDB
ZNF92
Tbio
Family: TF
Novelty: 0.05724663
p_int: 0.966354822
p_ni: 0.033581644
p_wrong: 0.000063534
Score: 0.189
Data Source: BioPlex,STRINGDB
POP4
Tbio
Family: Enzyme
Novelty: 0.01072287
p_int: 0.959835715
p_ni: 0.040164277
p_wrong: 8e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
MUM1
Tbio
Family: Epigenetic
Novelty: 0.11597088
p_int: 0.903895162
p_ni: 0.001691073
p_wrong: 0.094413765
Score: 0.269
Data Source: BioPlex,STRINGDB
BBX
Tbio
Family: TF
Novelty: 0.02157387
p_int: 0.86113603
p_ni: 0.138863951
p_wrong: 1.9e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.989
Data Source: STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
Score: 0.979
Data Source: Reactome,STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
Score: 0.977
Data Source: Reactome,STRINGDB
SMAD7
Tbio
Family: TF
Novelty: 0.00116343
Score: 0.974
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  202.22

PubMed score by year
PubTator Score  98.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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