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Tbio
NME8
Thioredoxin domain-containing protein 3

Protein Summary
Description
Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000199447
  • ENSP00000199447
  • ENSG00000086288
  • ENST00000440017
  • ENSP00000397063

Symbol
  • SPTRX2
  • TXNDC3
  • CILD6
  • SPTRX2
  • TXNDC3
  • NM23-H8
  • sptrx-2
  • HEL-S-99
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
biological process
0.78
tissue sample
0.76
cell type or tissue
0.7
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
1
1
1
66.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
1
66.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 family member 8
VGNC:14054
472348
Macaque
NME/NM23 family member 8
705583
Mouse
MGI:1920662
73412
Rat
RGD:735069
364729
Dog
NME/NM23 family member 8
VGNC:43859
609441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 family member 8
Macaque
NME/NM23 family member 8
Mouse
Rat
Dog
NME/NM23 family member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N427-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SYSCILIA_CCNET
Protein-Protein Interactions (192)
1 – 10 of 192
REPIN1
Tbio
Family: TF
Novelty: 0.01152362
p_int: 0.999990039
p_ni: 0.000009961
Score: 0.346
Data Source: BioPlex,STRINGDB
TRIM23
Tbio
Family: Enzyme
Novelty: 0.12751063
p_int: 0.999890009
p_ni: 0.000109991
Score: 0.416
Data Source: BioPlex,STRINGDB
DNAI2
Tbio
Novelty: 0.02801096
Score: 0.915
Data Source: STRINGDB
DNAH11
Tbio
Novelty: 0.02448234
Score: 0.903
Data Source: STRINGDB
DNAI1
Tbio
Novelty: 0.01021193
Score: 0.896
Data Source: STRINGDB
CCDC114
Tbio
Novelty: 0.12534741
Score: 0.884
Data Source: STRINGDB
DNAH5
Tbio
Novelty: 0.01579144
Score: 0.881
Data Source: STRINGDB
TXNRD1
Tclin
Family: Enzyme
Novelty: 0.00299018
Score: 0.859
Data Source: STRINGDB
TXNDC2
Tbio
Novelty: 0.10794522
Score: 0.849
Data Source: STRINGDB
ZCWPW1
Tbio
Family: Epigenetic
Novelty: 0.11264543
Score: 0.823
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.48

PubMed score by year
PubTator Score  12.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer