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Tchem
EIF2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

Protein Summary
Description
Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytoch ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.99
molecular function
0.97
disease perturbation
0.95
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.7   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.7   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
3
3
72.9
reticulocyte count
2
2
2
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
72.9
reticulocyte count
2
66.8
Pathways (5)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Protein processing in endoplasmic reticulum
KEGG
Hepatitis C
KEGG
Measles
KEGG
Herpes simplex virus 1 infection
Name
Explore in Pharos
Explore in Source
Protein processing in endoplasmic reticulum
Hepatitis C
Measles
Herpes simplex virus 1 infection
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (118)
1 – 10 of 118
CDK6
Tclin
Family: Kinase
Novelty: 0.00109319
p_int: 0.999999735
p_ni: 2.47e-7
p_wrong: 1.8e-8
Score: 0.283
Data Source: BioPlex,STRINGDB
DELE1
Tbio
Novelty: 0.096403
p_int: 0.999997879
p_ni: 7e-8
p_wrong: 0.000002051
Score: 0.547
Data Source: BioPlex,STRINGDB
FASLG
Tbio
Novelty: 0.0003303
p_int: 0.999994839
p_ni: 1.85e-7
p_wrong: 0.000004975
Score: 0.416
Data Source: BioPlex,STRINGDB
EIF2S1
Tbio
Novelty: 0.00076124
Score: 0.998
Data Source: STRINGDB
EIF2S3
Tbio
Novelty: 0.02055484
Score: 0.944
Data Source: STRINGDB
EIF2S2
Tbio
Novelty: 0.0146918
Score: 0.943
Data Source: STRINGDB
DNAJC3
Tbio
Novelty: 0.02129782
Score: 0.899
Data Source: STRINGDB
NFE2L2
Tchem
Family: TF
Novelty: 0.00043828
Score: 0.835
Data Source: STRINGDB
NFKBIA
Tchem
Novelty: 0.00022873
Score: 0.8
Data Source: STRINGDB
NFKBIB
Tbio
Novelty: 0.00517222
Score: 0.8
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.70

PubMed score by year
PubTator Score  102.98

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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