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Tbio
LAPTM4A
Lysosomal-associated transmembrane protein 4A

Protein Classes
Protein Summary
Description
May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000175091
  • ENSP00000175091
  • ENSG00000068697

Symbol
  • KIAA0108
  • LAPTM4
  • MBNT
  • MTRP
  • MBNT
  • Mtrp
  • LAPTM4
  • HUMORF13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
0.99
transcription factor binding site profile
0.96
transcription factor perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.17   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.17   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysosomal protein transmembrane 4 alpha
VGNC:286
459051
Macaque
lysosomal protein transmembrane 4 alpha
701298
Mouse
MGI:108017
17775
Rat
RGD:735179
298875
Dog
lysosomal protein transmembrane 4 alpha
VGNC:42583
475678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysosomal protein transmembrane 4 alpha
Macaque
lysosomal protein transmembrane 4 alpha
Mouse
Rat
Dog
lysosomal protein transmembrane 4 alpha
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15012-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (29)
1 – 10 of 29
C16orf58
Tdark
Novelty: 0.34461652
p_int: 0.998131999
p_ni: 0.000012401
p_wrong: 0.0018556
Score: 0.186
Data Source: BioPlex,STRINGDB
FAM234B
Tdark
Novelty: 1.53957047
p_int: 0.977188105
p_ni: 0.000001523
p_wrong: 0.022810372
Score: 0.188
Data Source: BioPlex,STRINGDB
TSPAN31
Tbio
Novelty: 0.13580467
p_int: 0.926798534
p_ni: 0.000022354
p_wrong: 0.073179112
Data Source: BioPlex
LAPTM5
Tbio
Novelty: 0.06809459
Score: 0.834
Data Source: STRINGDB
LAPTM4B
Tbio
Novelty: 0.01162533
Score: 0.817
Data Source: STRINGDB
KCNS3
Tclin
Family: IC
Novelty: 0.05882087
Score: 0.683
Data Source: STRINGDB
MATN3
Tbio
Novelty: 0.00426202
Score: 0.661
Data Source: STRINGDB
GTPBP4
Tbio
Novelty: 0.00062563
Score: 0.641
Data Source: STRINGDB
ARID4A
Tbio
Family: TF; Epigenetic
Novelty: 0.04953333
Score: 0.634
Data Source: STRINGDB
WDR35
Tbio
Novelty: 0.02958717
Score: 0.584
Data Source: STRINGDB
Publication Statistics
PubMed Score  225.17

PubMed score by year
PubTator Score  89.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer