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Tbio
KRT20
Keratin, type I cytoskeletal 20

Protein Summary
Description
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000167588
  • ENSP00000167588
  • ENSG00000171431
  • ENST00000576098
  • ENSP00000460501
  • ENSG00000263057

Symbol
  • K20
  • CD20
  • CK20
  • CK-20
  • KRT21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
disease perturbation
0.56
disease
0.55
biological term
0.54
cell type or tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 790.07   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 1141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 790.07   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 1141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Developmental Biology (R-HSA-1266738)

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Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (131)
1 – 10 of 131
KRT7
Tbio
Novelty: 0.00039796
Score: 0.939
Data Source: STRINGDB
KRT8
Tbio
Novelty: 0.00093008
Score: 0.938
Data Source: STRINGDB
KRT72
Tbio
Novelty: 0.06391566
Score: 0.938
Data Source: STRINGDB
KRT80
Tbio
Novelty: 0.08480792
Score: 0.935
Data Source: STRINGDB
KRT5
Tbio
Novelty: 0.00072336
Score: 0.934
Data Source: STRINGDB
KRT3
Tbio
Novelty: 0.00489796
Score: 0.933
Data Source: STRINGDB
KRT4
Tbio
Novelty: 0.00434637
Score: 0.928
Data Source: STRINGDB
KRT75
Tbio
Novelty: 0.00937304
Score: 0.926
Data Source: STRINGDB
KRT24
Tbio
Novelty: 0.06581895
Score: 0.925
Data Source: STRINGDB
KRT78
Tbio
Novelty: 0.08006367
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  790.07

PubMed score by year
PubTator Score  6653.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer