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Tchem
PYGM
Glycogen phosphorylase, muscle form

Protein Summary
Description
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000164139
  • ENSP00000164139
  • ENSG00000068976
  • ENST00000377432
  • ENSP00000366650
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
virus perturbation
0.72
cellular component
0.68
gene perturbation
0.66
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.71   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.71   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 79
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
1
1
29.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
29.6
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Glycogen breakdown (glycogenolysis) (R-HSA-70221)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (143)
1 – 10 of 143
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.994438883
p_ni: 0.005561117
Data Source: BioPlex
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.970883107
p_ni: 0.029116893
Data Source: BioPlex
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.963310671
p_ni: 0.036689329
Data Source: BioPlex
LZTR1
Tbio
Novelty: 0.02363333
p_int: 0.771414066
p_ni: 0.228585934
Data Source: BioPlex
TLE3
Tbio
Novelty: 0.02641884
p_int: 0.75155618
p_ni: 0.24844382
Score: 0.29
Data Source: BioPlex,STRINGDB
GBE1
Tbio
Family: Enzyme
Novelty: 0.00233237
Score: 0.993
Data Source: STRINGDB
AGL
Tbio
Novelty: 0.00166875
Score: 0.992
Data Source: STRINGDB
PYGB
Tbio
Family: Enzyme
Novelty: 0.00224148
Score: 0.98
Data Source: STRINGDB
PGM1
Tbio
Family: Enzyme
Novelty: 0.00163947
Score: 0.978
Data Source: STRINGDB
PHKG1
Tchem
Family: Kinase
Novelty: 0.08576384
Score: 0.975
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  177.71

PubMed score by year
PubTator Score  264.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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