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Tbio
ACTL6B
Actin-like protein 6B

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000160382
  • ENSP00000160382
  • ENSG00000077080

Symbol
  • ACTL6
  • BAF53B
  • ACTL6
  • BAF53B
  • arpNalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.56
cellular component
0.52
biological process
0.47
gene perturbation
0.45
tissue
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
39.5
hematocrit
1
1
1
25.6
mean platelet volume
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
39.5
hematocrit
1
25.6
mean platelet volume
1
4.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin like 6B
VGNC:4246
739528
Macaque
actin like 6B
712643
Mouse
MGI:1933548
83766
Rat
RGD:1307763
288563
Dog
actin like 6B
VGNC:37543
608417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin like 6B
Macaque
actin like 6B
Mouse
Rat
Dog
actin like 6B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94805-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Protein-Protein Interactions (178)
1 – 10 of 178
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.999981759
p_ni: 0.000018232
p_wrong: 1e-8
Score: 0.542
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999939766
p_ni: 0.000060234
Score: 0.257
Data Source: BioPlex,STRINGDB
ZNHIT1
Tbio
Novelty: 0.00390514
p_int: 0.999899194
p_ni: 0.000100806
Score: 0.486
Data Source: BioPlex,STRINGDB
SS18
Tbio
Novelty: 0.00915548
p_int: 0.999597804
p_ni: 0.000402196
Score: 0.918
Data Source: BioPlex,STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.999589312
p_ni: 0.000410687
p_wrong: 1e-9
Score: 0.787
Data Source: BioPlex,STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.999231335
p_ni: 0.000768664
p_wrong: 1e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
INO80
Tbio
Family: Enzyme
Novelty: 0.09412936
p_int: 0.999149931
p_ni: 0.000846061
p_wrong: 0.000004008
Score: 0.832
Data Source: BioPlex,STRINGDB
DMAP1
Tbio
Family: Enzyme
Novelty: 0.03152166
p_int: 0.998730907
p_ni: 0.001256637
p_wrong: 0.000012456
Score: 0.856
Data Source: BioPlex,STRINGDB
SMARCD1
Tbio
Novelty: 0.03176642
p_int: 0.998353324
p_ni: 0.001646676
Score: 0.991
Data Source: BioPlex,STRINGDB
SMARCB1
Tbio
Novelty: 0.00116387
p_int: 0.997972672
p_ni: 0.001831492
p_wrong: 0.000195836
Score: 0.992
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  20.31

PubMed score by year
PubTator Score  6.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer