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Tbio
CTTNBP2
Cortactin-binding protein 2

Protein Summary
Description
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance. This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000160373
  • ENSP00000160373
  • ENSG00000077063

Symbol
  • C7orf8
  • CORTBP2
  • KIAA1758
  • Orf4
  • C7orf8
  • CORTBP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.62
PubMedID
0.61
small molecule perturbation
0.56
microRNA
0.55
cell line
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
0
1
95.5
smoking cessation
1
1
1
82.2
self reported educational attainment
2
2
2
82.1
wellbeing measurement
2
1
2
81.8
4
2
3
1
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
1
95.5
smoking cessation
1
82.2
self reported educational attainment
2
82.1
wellbeing measurement
2
81.8
3
1
75.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cortactin binding protein 2
VGNC:4325
463675
Macaque
cortactin binding protein 2
705351
Mouse
MGI:1353467
30785
Rat
RGD:628691
282587
Dog
cortactin binding protein 2
VGNC:39719
100687879
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cortactin binding protein 2
Macaque
cortactin binding protein 2
Mouse
Rat
Dog
cortactin binding protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WZ74-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (78)
1 – 10 of 78
STRN3
Tbio
Novelty: 0.10331283
p_int: 0.999999806
p_ni: 1.94e-7
Score: 0.906
Data Source: BioPlex,STRINGDB
STRN
Tbio
Novelty: 0.01025814
p_int: 0.999996994
p_ni: 0.000003006
Score: 0.947
Data Source: BioPlex,STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
p_int: 0.999748645
p_ni: 0.000250954
p_wrong: 4.02e-7
Score: 0.894
Data Source: BioPlex,STRINGDB
PRDM14
Tbio
Family: TF; Epigenetic
Novelty: 0.01776592
p_int: 0.997498142
p_ni: 0.002501857
Score: 0.274
Data Source: BioPlex,STRINGDB
CCDC136
Tbio
Novelty: 0.09279967
p_int: 0.799322366
p_ni: 0.002326716
p_wrong: 0.198350917
Score: 0.248
Data Source: BioPlex,STRINGDB
STRIP1
Tbio
Novelty: 0.13320106
Score: 0.925
Data Source: STRINGDB
CWC15
Tbio
Novelty: 0.00205068
Score: 0.921
Data Source: STRINGDB
STRIP2
Tbio
Novelty: 0.19321125
Score: 0.915
Data Source: STRINGDB
MOB4
Tbio
Novelty: 0.03238981
Score: 0.91
Data Source: STRINGDB
STK26
Tchem
Family: Kinase
Novelty: 0.03633178
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  397.07

PubMed score by year
PubTator Score  106.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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