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Tbio
ICAM3
Intercellular adhesion molecule 3

Protein Summary
Description
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000160262
  • ENSP00000160262
  • ENSG00000076662

Symbol
  • CD50
  • CDW50
  • ICAM-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
phenotype
0.77
tissue sample
0.68
disease
0.64
tissue
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.83   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 1394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.83   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 1394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
34.1
1
1
0
1.2
34.1
lymphocyte count
2
1
2
9.3
monocyte count
1
1
1
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
34.1
0
1.2
34.1
lymphocyte count
2
9.3
monocyte count
1
6.4
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intercellular adhesion molecule 3
VGNC:2350
494138
Macaque
intercellular adhesion molecule 3
715298
Horse
intercellular adhesion molecule 3
VGNC:18929
100058074
Cow
intercellular adhesion molecule 3
VGNC:50198
281840
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intercellular adhesion molecule 3
Macaque
intercellular adhesion molecule 3
Horse
intercellular adhesion molecule 3
Cow
intercellular adhesion molecule 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32942-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
Extracellular matrix organization
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Extracellular matrix organization
Immune System
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (85)
1 – 10 of 85
ZNF431
Tdark
Family: TF
Novelty: 1.38008368
p_int: 0.953367488
p_ni: 4.1e-8
p_wrong: 0.046632471
Score: 0.416
Data Source: BioPlex,STRINGDB
TMEM192
Tbio
Novelty: 0.30699087
p_int: 0.927693946
p_ni: 0.072306018
p_wrong: 3.6e-8
Score: 0.239
Data Source: BioPlex,STRINGDB
FUT8
Tbio
Family: Enzyme
Novelty: 0.00675388
p_int: 0.815657416
p_ni: 0.184342584
Score: 0.287
Data Source: BioPlex,STRINGDB
ITGAL
Tclin
Novelty: 0.00099016
Score: 0.997
Data Source: STRINGDB
CD209
Tbio
Novelty: 0.001172
Score: 0.997
Data Source: Reactome,STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.968
Data Source: STRINGDB
ITGAD
Tbio
Novelty: 0.01613546
Score: 0.954
Data Source: STRINGDB
ICAM2
Tbio
Novelty: 0.00480584
Score: 0.842
Data Source: STRINGDB
CLEC4M
Tbio
Novelty: 0.00695285
Score: 0.833
Data Source: STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
Score: 0.814
Data Source: STRINGDB
Publication Statistics
PubMed Score  410.83

PubMed score by year
PubTator Score  145.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer