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Tbio
APPBP2
Amyloid protein-binding protein 2

Protein Summary
Description
May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000083182
  • ENSP00000083182
  • ENSG00000062725

Symbol
  • KIAA0228
  • PAT1
  • PAT1
  • APP-BP2
  • HS.84084
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.91
hub protein
0.79
transcription factor binding site profile
0.73
cell line
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (70)
1 – 10 of 70
COPS2
Tbio
Novelty: 0.03509351
p_int: 0.999997276
p_ni: 0.000002724
Score: 0.53
Data Source: BioPlex,STRINGDB
COPS8
Tbio
Novelty: 0.0408885
p_int: 0.999974702
p_ni: 0.000025166
p_wrong: 1.31e-7
Score: 0.51
Data Source: BioPlex,STRINGDB
CUL2
Tbio
Novelty: 0.00512916
p_int: 0.999969541
p_ni: 0.000030459
Score: 0.242
Data Source: BioPlex,STRINGDB
GLMN
Tbio
Novelty: 0.01940401
p_int: 0.999939066
p_ni: 0.000060876
p_wrong: 5.8e-8
Data Source: BioPlex
COPS7B
Tbio
Novelty: 0.63421506
p_int: 0.999812419
p_ni: 0.000187581
Score: 0.216
Data Source: BioPlex,STRINGDB
DOCK8
Tbio
Novelty: 0.0067047
p_int: 0.999258425
p_ni: 0.000741575
Data Source: BioPlex
C1QTNF2
Tbio
Novelty: 0.18607978
p_int: 0.999221892
p_ni: 0.000777837
p_wrong: 2.71e-7
Data Source: BioPlex
XRCC4
Tbio
Novelty: 0.00305644
p_int: 0.99920304
p_ni: 0.00079696
Score: 0.205
Data Source: BioPlex,STRINGDB
INTU
Tbio
Novelty: 0.02714388
p_int: 0.998568328
p_ni: 0.001431669
p_wrong: 3e-9
Data Source: BioPlex
COPS3
Tbio
Novelty: 0.04664225
p_int: 0.993481028
p_ni: 0.00651721
p_wrong: 0.000001762
Score: 0.542
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  5.44

PubMed score by year
PubTator Score  29.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer