Protein Classes
Protein Summary
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alter ...more
- ENST00000064724
- ENSP00000064724
- ENSG00000013297
- OSP
- OTM
- OSP
- OTM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug perturbation | 0.87 | ||
microRNA | 0.77 | ||
small molecule perturbation | 0.69 | ||
PubMedID | 0.68 | ||
cell type or tissue | 0.64 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 387.9 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 301 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 387.9 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 301 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (25)
Reactome (4)
KEGG (4)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Tight junction interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Tight junction interactions | ||||
Gene Ontology Terms (6)
Functions (2)
Components (3)
Processes (1)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (67)
1 – 10 of 67
CLDN12
Novelty: 0.06470623
Score: 0.956
Data Source: STRINGDB
CLDN23
Novelty: 0.16372511
Score: 0.947
Data Source: STRINGDB
CLDN14
Novelty: 0.02451529
Score: 0.922
Data Source: STRINGDB
CLDN16
Novelty: 0.0103486
Score: 0.92
Data Source: STRINGDB
CLDN5
Novelty: 0.00230537
Score: 0.919
Data Source: STRINGDB
CLDN2
Novelty: 0.00319519
Score: 0.917
Data Source: STRINGDB
CLDN6
Novelty: 0.01627077
Score: 0.917
Data Source: STRINGDB
CLDN9
Novelty: 0.10826674
Score: 0.916
Data Source: STRINGDB
CLDN3
Novelty: 0.00374279
Score: 0.916
Data Source: STRINGDB
CLDN19
Novelty: 0.03007126
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score 387.90
PubMed score by year
PubTator Score 119.32
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MVATCLQVVGFVTSFVGWIGVIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLVD
1-70
ILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIW
70-140
FPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYYTAGSSSPTHAKSAHV
140-207
MVATCLQVVGFVTSFVGWIGVIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYYTAGSSSPTHAKSAHV
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