You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RFC2
Replication factor C subunit 2

Protein Summary
Description
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000055077
  • ENSP00000055077
  • ENSG00000049541
  • ENST00000352131
  • ENSP00000275627

Symbol
  • RFC40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
protein complex
1
molecular function
0.97
hub protein
0.88


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.31   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 424   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.31   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
replication factor C subunit 2
693548
Mouse
MGI:1341868
19718
Rat
RGD:621198
116468
Dog
replication factor C subunit 2
VGNC:45493
489798
Horse
replication factor C subunit 2
VGNC:22319
100059980
Species
Name
OMA
EggNOG
Inparanoid
Macaque
replication factor C subunit 2
Mouse
Rat
Dog
replication factor C subunit 2
Horse
replication factor C subunit 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35250-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (59)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 52
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Base Excision Repair
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (295)
1 – 10 of 295
RFC4
Tbio
Novelty: 0.03232586
p_int: 0.999994269
p_ni: 0.000005731
Score: 0.999
Data Source: BioPlex,STRINGDB
RFC5
Tbio
Novelty: 0.03987481
p_int: 0.999355387
p_ni: 0.000644613
Score: 0.999
Data Source: BioPlex,STRINGDB
DSCC1
Tbio
Novelty: 0.04747149
p_int: 0.998948701
p_ni: 0.001051299
Score: 0.996
Data Source: BioPlex,STRINGDB
RAD17
Tbio
Novelty: 0.00640979
p_int: 0.903946085
p_ni: 0.096053915
Score: 0.999
Data Source: BioPlex,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.999
Data Source: STRINGDB
RFC3
Tbio
Novelty: 0.02712951
Score: 0.999
Data Source: STRINGDB
CHTF18
Tbio
Novelty: 0.02470494
Score: 0.998
Data Source: STRINGDB
RFC1
Tbio
Novelty: 0.02642014
Score: 0.998
Data Source: STRINGDB
PRIM1
Tbio
Family: Enzyme
Novelty: 0.0530384
Score: 0.991
Data Source: STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.31

PubMed score by year
PubTator Score  14.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer