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Tbio
UTS2
Urotensin-2

Protein Classes
Protein Summary
Description
Highly potent vasoconstrictor. This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000054668
  • ENSP00000054668
  • ENSG00000049247
  • ENST00000361696
  • ENSP00000355163

Symbol
  • UII
  • U-II
  • UCN2
  • PRO1068
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
cell type or tissue
0.76
biological term
0.72
gene perturbation
0.57
tissue
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.45   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.45   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
77.9
hair color
1
1
0
1.1
4.5
1
1
0
1.1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
77.9
hair color
0
1.1
4.5
0
1.1
4.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
urotensin 2
VGNC:10899
746007
Macaque
urotensin 2
574246
Mouse
MGI:1346329
24111
Rat
RGD:3930
29180
Opossum
urotensin 2
103106245
Species
Name
OMA
EggNOG
Inparanoid
Chimp
urotensin 2
Macaque
urotensin 2
Mouse
Rat
Opossum
urotensin 2
Pathways (15)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (185)
1 – 10 of 185
UTS2R
Tchem
Family: GPCR
Novelty: 0.00865846
Score: 0.994
Data Source: Reactome,STRINGDB
UTS2B
Tbio
Novelty: 0.04307669
Score: 0.982
Data Source: STRINGDB
EDN1
Tbio
Novelty: 0.00007453
Score: 0.958
Data Source: STRINGDB
MCHR2
Tchem
Family: GPCR
Novelty: 0.01191922
Score: 0.956
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.933
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.933
Data Source: STRINGDB
NMU
Tbio
Novelty: 0.00326109
Score: 0.931
Data Source: STRINGDB
NMBR
Tchem
Family: GPCR
Novelty: 0.01642469
Score: 0.93
Data Source: STRINGDB
EDN2
Tbio
Novelty: 0.00203492
Score: 0.929
Data Source: STRINGDB
HCRT
Tbio
Novelty: 0.00034048
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  439.45

PubMed score by year
PubTator Score  381.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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