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Tbio
GRN
Granulins

Protein Summary
Description
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000053867
  • ENSP00000053867
  • ENSG00000030582
  • ENST00000639447
  • ENSP00000492014

Symbol
  • GEP
  • GP88
  • PEPI
  • PGRN
  • CLN11
  • PCDGF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
viral protein
1
biological term
0.99
disease perturbation
0.99
transcription factor perturbation
0.99


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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1205.83   (req: < 5)
Gene RIFs: 360   (req: <= 3)
Antibodies: 532   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1205.83   (req: >= 5)
Gene RIFs: 360   (req: > 3)
Antibodies: 532   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
progranulin measurement
1
1
1
72.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
progranulin measurement
1
72.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
granulin precursor
VGNC:9311
454728
Macaque
granulin precursor
714851
Mouse
MGI:95832
14824
Rat
RGD:61983
29143
Dog
granulin precursor
VGNC:41516
480501
Species
Name
OMA
EggNOG
Inparanoid
Chimp
granulin precursor
Macaque
granulin precursor
Mouse
Rat
Dog
granulin precursor
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28799-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (249)
1 – 10 of 249
OTUD5
Tbio
Novelty: 0.0498487
p_int: 0.999733208
p_ni: 0.000014938
p_wrong: 0.000251854
Score: 0.303
Data Source: BioPlex,STRINGDB
ZFP41
Tdark
Family: TF
Novelty: 3.33093006
p_int: 0.999190149
p_ni: 0.000809851
Data Source: BioPlex
FBXO6
Tbio
Novelty: 0.02173918
p_int: 0.999181819
p_ni: 0.00081818
Data Source: BioPlex
CTSO
Tbio
Family: Enzyme
Novelty: 0.09963965
p_int: 0.999164815
p_ni: 0.000835185
Score: 0.446
Data Source: BioPlex,STRINGDB
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.998649903
p_ni: 0.001350097
Score: 0.25
Data Source: BioPlex,STRINGDB
ZC3HC1
Tbio
Novelty: 0.089692
p_int: 0.99787554
p_ni: 0.002115369
p_wrong: 0.000009091
Score: 0.183
Data Source: BioPlex,STRINGDB
PKP2
Tbio
Novelty: 0.00493803
p_int: 0.997709132
p_ni: 0.002290867
p_wrong: 1e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
CD68
Tbio
Novelty: 0.00017859
p_int: 0.996312756
p_ni: 0.003687205
p_wrong: 4e-8
Score: 0.649
Data Source: BioPlex,STRINGDB
NAB2
Tbio
Novelty: 0.00860107
p_int: 0.995135497
p_ni: 0.004864491
p_wrong: 1.2e-8
Data Source: BioPlex
BMT2
Tbio
Family: Enzyme
Novelty: 0.05916379
p_int: 0.991580455
p_ni: 0.008416483
p_wrong: 0.000003062
Data Source: BioPlex
Publication Statistics
PubMed Score  1205.83

PubMed score by year
PubTator Score  1118.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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