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Tbio
XYLT2
Xylosyltransferase 2

Protein Summary
Description
Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000017003
  • ENSP00000017003
  • ENSG00000015532

Symbol
  • XT2
  • SOS
  • XT2
  • XT-II
  • PXYLT2
  • xylT-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.74
kinase perturbation
0.71
cell line
0.65
cell type or tissue
0.65
histone modification site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.92   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.92   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (11)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Protein-Protein Interactions (80)
1 – 10 of 80
POMK
Tbio
Family: Kinase
Novelty: 0.09340344
p_int: 0.989339796
p_ni: 0.010660204
Score: 0.605
Data Source: BioPlex,STRINGDB
TNFSF18
Tbio
Novelty: 0.01423949
p_int: 0.979095569
p_ni: 0.020904104
p_wrong: 3.27e-7
Data Source: BioPlex
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.973355891
p_ni: 0.026644106
p_wrong: 3e-9
Data Source: BioPlex
B4GALT3
Tbio
Family: Enzyme
Novelty: 0.04015046
p_int: 0.952482097
p_ni: 0.047517903
Score: 0.617
Data Source: BioPlex,STRINGDB
GPC1
Tbio
Novelty: 0.00293087
p_int: 0.947821953
p_ni: 0.052178046
p_wrong: 1e-9
Score: 0.926
Data Source: BioPlex,STRINGDB
UST
Tbio
Family: Enzyme
Novelty: 0.03897672
p_int: 0.930197642
p_ni: 0.069802339
p_wrong: 1.9e-8
Score: 0.521
Data Source: BioPlex,STRINGDB
GPC3
Tbio
Novelty: 0.00151823
p_int: 0.927068772
p_ni: 0.072922525
p_wrong: 0.000008703
Score: 0.918
Data Source: BioPlex,STRINGDB
RETREG3
Tdark
Novelty: 0.99215801
p_int: 0.921564162
p_ni: 0.078434793
p_wrong: 0.000001044
Score: 0.356
Data Source: BioPlex,STRINGDB
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.919239894
p_ni: 0.080757018
p_wrong: 0.000003087
Data Source: BioPlex
CLEC2D
Tbio
Novelty: 0.02501194
p_int: 0.904267073
p_ni: 0.095732807
p_wrong: 1.2e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  367.92

PubMed score by year
PubTator Score  75.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer