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Tbio
CACNG3
Voltage-dependent calcium channel gamma-3 subunit

Protein Summary
Description
Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005284
  • ENSP00000005284
  • ENSG00000006116
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
gene perturbation
0.55
cell line
0.53
cellular component
0.53
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.55   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.55   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (24)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
LGI-ADAM interactions
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Developmental Biology
Glutamate binding, activation of AMPA receptors and synaptic plasticity
LGI-ADAM interactions
Muscle contraction
Protein-Protein Interactions (180)
1 – 10 of 180
POTEF
Tbio
Novelty: 0.01093698
p_int: 0.996926827
p_ni: 0.003073172
Score: 0.208
Data Source: BioPlex,STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00071387
p_int: 0.985430354
p_ni: 0.014569646
Score: 0.268
Data Source: BioPlex,STRINGDB
CACNB1
Tbio
Family: IC
Novelty: 0.11709553
Score: 0.972
Data Source: STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.0266267
Score: 0.964
Data Source: STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.06538322
Score: 0.955
Data Source: STRINGDB
CAMK2A
Tchem
Family: Kinase
Novelty: 0.01196206
Score: 0.953
Data Source: STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00242625
Score: 0.949
Data Source: STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.02329242
Score: 0.945
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.00063312
Score: 0.944
Data Source: STRINGDB
CACNG1
Tbio
Family: IC
Novelty: 0.174255
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.55

PubMed score by year
PubTator Score  3.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer