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Tbio
HS3ST1
Heparan sulfate glucosamine 3-O-sulfotransferase 1

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000002596
  • ENSP00000002596
  • ENSG00000002587

Symbol
  • 3OST
  • 3OST1
  • 3OST
  • 3OST1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
gene perturbation
0.96
PubMedID
0.87
histone modification site profile
0.67
tissue
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (71)
1 – 10 of 71
SDC2
Tbio
Novelty: 0.00597758
Score: 0.954
Data Source: STRINGDB
HSPG2
Tbio
Family: Enzyme
Novelty: 0.00159541
Score: 0.948
Data Source: STRINGDB
GPC1
Tbio
Novelty: 0.00293087
Score: 0.948
Data Source: STRINGDB
GPC4
Tbio
Novelty: 0.01319626
Score: 0.947
Data Source: STRINGDB
GPC3
Tbio
Novelty: 0.00151823
Score: 0.946
Data Source: STRINGDB
GPC2
Tbio
Novelty: 0.02182363
Score: 0.945
Data Source: STRINGDB
GPC6
Tbio
Novelty: 0.01951872
Score: 0.944
Data Source: STRINGDB
GPC5
Tbio
Novelty: 0.01257358
Score: 0.939
Data Source: STRINGDB
SDC1
Tbio
Novelty: 0.00044792
Score: 0.935
Data Source: STRINGDB
SDC3
Tbio
Novelty: 0.01095269
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.14

PubMed score by year
PubTator Score  12.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer