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Tbio
ENSA
Alpha-endosulfine

Protein Summary
Description
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271690
  • ENSP00000271690
  • ENSG00000143420
  • ENST00000339643
  • ENSP00000341743
  • ENST00000361532
  • ENSP00000354835
  • ENST00000361631
  • ENSP00000355239
  • ENST00000362052
  • ENSP00000355220
  • ENST00000369014
  • ENSP00000358010
  • ENST00000503241
  • ENSP00000424242
  • ENST00000503345
  • ENSP00000421458
  • ENST00000509582
  • ENSP00000426110
  • ENST00000513281
  • ENSP00000422343

Symbol
  • ARPP-19e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
gene perturbation
0.88
co-expressed gene
0.85
transcription factor
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.19   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.19   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0