You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ENSA
Alpha-endosulfine

Protein Summary
Description
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271690
  • ENSP00000271690
  • ENSG00000143420
  • ENST00000339643
  • ENSP00000341743
  • ENST00000361532
  • ENSP00000354835
  • ENST00000361631
  • ENSP00000355239
  • ENST00000362052
  • ENSP00000355220
  • ENST00000369014
  • ENSP00000358010
  • ENST00000503241
  • ENSP00000424242
  • ENST00000503345
  • ENSP00000421458
  • ENST00000509582
  • ENSP00000426110
  • ENST00000513281
  • ENSP00000422343

Symbol
  • ARPP-19e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
gene perturbation
0.88
co-expressed gene
0.85
transcription factor
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.65   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.65   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
OFD1
Tbio
Novelty:  0.01032841
p_int:  0.999725561
p_ni:  0.000274433
p_wrong:  6e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.999524149
p_ni:  0.000475783
p_wrong:  6.9e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.999326835
p_ni:  0.000673163
p_wrong:  2e-9
Data Source:  BioPlex
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
p_int:  0.999110736
p_ni:  0.00088904
p_wrong:  2.23e-7
Score:  0.182
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.998425195
p_ni:  0.001574805
Data Source:  BioPlex
QSOX1
Tbio
Family:  Enzyme
Novelty:  0.02152583
p_int:  0.996501465
p_ni:  0.003498514
p_wrong:  2.1e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.995960667
p_ni:  0.00403933
p_wrong:  2e-9
Score:  0.155
Data Source:  BioPlex,STRINGDB
CBX5
Tbio
Family:  Epigenetic
Novelty:  0.00653413
p_int:  0.984677321
p_ni:  0.015322678
Data Source:  BioPlex
IREB2
Tbio
Novelty:  0.00300491
p_int:  0.960357936
p_ni:  0.039628027
p_wrong:  0.000014036
Data Source:  BioPlex
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.911124727
p_ni:  0.088875269
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
M Phase
Reactome
MASTL Facilitates Mitotic Progression
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
M Phase
MASTL Facilitates Mitotic Progression
Mitotic Prophase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
4
4
97.2
eosinophil count
3
3
5
96.8
lymphocyte count
3
3
3
93
granulocyte percentage of myeloid white cells
1
2
2
93
eosinophil percentage of leukocytes
2
2
3
91.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
4
97.2
eosinophil count
5
96.8
lymphocyte count
3
93
granulocyte percentage of myeloid white cells
2
93
eosinophil percentage of leukocytes
3
91.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endosulfine alpha
VGNC:10611
457275
Macaque
endosulfine alpha
715857
Mouse
MGI:1891189
56205
Rat
RGD:62007
60334
Dog
endosulfine alpha
VGNC:40379
475837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endosulfine alpha
Macaque
endosulfine alpha
Mouse
Rat
Dog
endosulfine alpha
Publication Statistics
PubMed Score 60.65
PubMed score by year
PubTator Score 26.57
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title