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Tbio
ENPP4
Bis(5'-adenosyl)-triphosphatase ENPP4

Protein Summary
Description
Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321037
  • ENSP00000318066
  • ENSG00000001561

Symbol
  • KIAA0879
  • NPP4
  • NPP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
protein domain
0.73
microRNA
0.68
disease perturbation
0.62
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.95   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.95   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
LSMEM2
Tdark
Novelty:  43
p_int:  0.999999859
p_ni:  2.7e-8
p_wrong:  1.14e-7
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999985325
p_ni:  0.000013361
p_wrong:  0.000001315
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.999980238
p_ni:  0.000011119
p_wrong:  0.000008644
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.999959374
p_ni:  0.000040616
p_wrong:  1e-8
Score:  0.239
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999816293
p_ni:  0.000183082
p_wrong:  6.26e-7
Score:  0.311
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.99966351
p_ni:  0.000326429
p_wrong:  0.000010061
Score:  0.248
Data Source:  BioPlex,STRINGDB
ANKH
Tbio
Novelty:  0.00995443
p_int:  0.999045832
p_ni:  0.00007755
p_wrong:  0.000876618
Data Source:  BioPlex
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
p_int:  0.978190109
p_ni:  0.000146229
p_wrong:  0.021663661
Score:  0.163
Data Source:  BioPlex,STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.943149082
p_ni:  0.000716774
p_wrong:  0.056134144
Score:  0.159
Data Source:  BioPlex,STRINGDB
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.913464151
p_ni:  0.001074237
p_wrong:  0.085461612
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
10.4
mean reticulocyte volume
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
10.4
mean reticulocyte volume
1
10.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectonucleotide pyrophosphatase/phosphodiesterase 4
VGNC:48970
462740
Mouse
MGI:2682634
224794
Rat
RGD:1308689
301261
Dog
ectonucleotide pyrophosphatase/phosphodiesterase 4
VGNC:49603
481823
Horse
ectonucleotide pyrophosphatase/phosphodiesterase 4
VGNC:50478
100068264
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectonucleotide pyrophosphatase/phosphodiesterase 4
Mouse
Rat
Dog
ectonucleotide pyrophosphatase/phosphodiesterase 4
Horse
ectonucleotide pyrophosphatase/phosphodiesterase 4
Publication Statistics
PubMed Score 10.95
PubMed score by year
PubTator Score 5.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title