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Tchem
ENPEP
Glutamyl aminopeptidase

Protein Summary
Description
Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265162
  • ENSP00000265162
  • ENSG00000138792

Symbol
  • APA
  • CD249
  • gp160
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
gene perturbation
0.76
cellular component
0.71
kinase perturbation
0.71
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 838.39   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 456   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 838.39   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (45)
CHEMBL88808
Rendered image for CHEMBL88808
CHEMBL146746
Rendered image for CHEMBL146746
CHEMBL358903
Rendered image for CHEMBL358903
CHEMBL348205
Rendered image for CHEMBL348205
CHEMBL148777
Rendered image for CHEMBL148777
CHEMBL151631
Rendered image for CHEMBL151631
CHEMBL147285
Rendered image for CHEMBL147285
CHEMBL359101
Rendered image for CHEMBL359101
Protein-Protein Interactions (76)
FRMD5
Tbio
Novelty:  0.34991399
p_int:  0.981933089
p_ni:  0.008895821
p_wrong:  0.00917109
Score:  0.407
Data Source:  BioPlex,STRINGDB
BNIP3
Tbio
Novelty:  0.00216392
p_int:  0.947875827
p_ni:  0.015232335
p_wrong:  0.036891838
Score:  0.37
Data Source:  BioPlex,STRINGDB
AGT
Tbio
Novelty:  0.00049613
Score:  0.971
Data Source:  Reactome,STRINGDB
ITIH4
Tbio
Novelty:  0.00032471
Score:  0.915
Data Source:  STRINGDB
RPL22
Tbio
Novelty:  0.00473197
Score:  0.767
Data Source:  STRINGDB
DNPEP
Tchem
Family:  Enzyme
Novelty:  0.02415651
Score:  0.76
Data Source:  STRINGDB
GPR160
Tbio
Family:  GPCR
Novelty:  0.15856538
Score:  0.758
Data Source:  STRINGDB
REN
Tclin
Family:  Enzyme
Novelty:  0.00002435
Score:  0.682
Data Source:  STRINGDB
ACE2
Tchem
Family:  Enzyme
Novelty:  0.00028408
Score:  0.676
Data Source:  STRINGDB
CRYGD
Tbio
Novelty:  0.00246109
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Peptide hormone metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.1
94.9
myeloid white cell count
1
1
1
68.8
Agents acting on the renin-angiotensin system use measurement
1
2
2
66.6
Calcium channel blocker use measurement
1
2
2
64.2
metabolite measurement
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94.9
myeloid white cell count
1
68.8
Agents acting on the renin-angiotensin system use measurement
2
66.6
Calcium channel blocker use measurement
2
64.2
metabolite measurement
1
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamyl aminopeptidase
VGNC:6420
461437
Macaque
glutamyl aminopeptidase
699615
Mouse
MGI:106645
13809
Rat
RGD:621228
64017
Dog
glutamyl aminopeptidase
VGNC:40373
478517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamyl aminopeptidase
Macaque
glutamyl aminopeptidase
Mouse
Rat
Dog
glutamyl aminopeptidase
Publication Statistics
PubMed Score 838.39
PubMed score by year
PubTator Score 786.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title