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Tbio
ENOX1
Ecto-NOX disulfide-thiol exchanger 1

Protein Summary
Description
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the other is at its lowest. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261488
  • ENSP00000261488
  • ENSG00000120658

Symbol
  • CNOX
  • PIG38
  • cCNOX
  • bA64J21.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
kinase perturbation
0.71
transcription factor binding site profile
0.7
transcription factor
0.67
phenotype
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.24   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.24   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
POP5
Tbio
Family:  Enzyme
Novelty:  0.02459167
p_int:  0.999999923
p_ni:  6.7e-8
p_wrong:  1.1e-8
Data Source:  BioPlex
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999999859
p_ni:  7.7e-8
p_wrong:  6.3e-8
Data Source:  BioPlex
TRIM33
Tchem
Family:  Epigenetic
Novelty:  0.00415877
Score:  0.742
Data Source:  STRINGDB
ENOX2
Tbio
Novelty:  0.02921191
Score:  0.709
Data Source:  STRINGDB
RETREG3
Tdark
Novelty:  0.99215801
Score:  0.606
Data Source:  STRINGDB
ZFAND5
Tbio
Novelty:  0.09728886
Score:  0.563
Data Source:  STRINGDB
IQCN
Tdark
Novelty:  2.74045479
Score:  0.546
Data Source:  STRINGDB
KIF24
Tbio
Novelty:  0.13497665
Score:  0.543
Data Source:  STRINGDB
KDELC2
Tdark
Novelty:  0.7820617
Score:  0.521
Data Source:  STRINGDB
GREB1
Tbio
Novelty:  0.01644388
Score:  0.509
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.6
84.6
3
1
0
1.2
73.9
1
1
0
1.1
65.3
1
1
0
1.1
40.7
2
1
0
1.1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
84.6
0
1.2
73.9
0
1.1
65.3
0
1.1
40.7
0
1.1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ecto-NOX disulfide-thiol exchanger 1
VGNC:14537
452567
Macaque
ecto-NOX disulfide-thiol exchanger 1
700475
Mouse
MGI:2444896
239188
Rat
RGD:1306118
306038
Dog
ecto-NOX disulfide-thiol exchanger 1
VGNC:40371
609336
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ecto-NOX disulfide-thiol exchanger 1
Macaque
ecto-NOX disulfide-thiol exchanger 1
Mouse
Rat
Dog
ecto-NOX disulfide-thiol exchanger 1
Publication Statistics
PubMed Score 14.24
PubMed score by year
PubTator Score 23.20
PubTator score by year
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Related Publications
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PMID
Year
Title