You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ENO3
Beta-enolase

Protein Summary
Description
Appears to have a function in striated muscle development and regeneration. This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323997
  • ENSP00000324105
  • ENSG00000108515
  • ENST00000518175
  • ENSP00000431087
  • ENST00000519584
  • ENSP00000430636

Symbol
  • MSE
  • GSD13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.87
protein domain
0.85
disease perturbation
0.83
transcription factor
0.79
gene perturbation
0.77


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.5   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 353   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.5   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
ENO2
Tbio
Family:  Enzyme
Novelty:  0.00016748
p_int:  1
Score:  0.962
Data Source:  BioPlex,STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
p_int:  0.999902403
p_ni:  0.000097597
Score:  0.962
Data Source:  BioPlex,STRINGDB
PGAM1
Tchem
Family:  Enzyme
Novelty:  0.0111272
Score:  0.994
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.989
Data Source:  STRINGDB
PKLR
Tbio
Family:  Kinase
Novelty:  0.00268398
Score:  0.985
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.983
Data Source:  STRINGDB
PGAM2
Tbio
Family:  Enzyme
Novelty:  0.02438933
Score:  0.983
Data Source:  STRINGDB
BPGM
Tbio
Family:  Enzyme
Novelty:  0.03437401
Score:  0.963
Data Source:  STRINGDB
TPI1
Tbio
Family:  Enzyme
Novelty:  0.00074652
Score:  0.961
Data Source:  STRINGDB
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
7
8
4.2
98.7
mean platelet volume
3
5
7
96.6
platelet crit
2
3
3
92.4
blood metabolite measurement
2
2
2
89
sphingomyelin measurement
1
2
3
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
8
4.2
98.7
mean platelet volume
7
96.6
platelet crit
3
92.4
blood metabolite measurement
2
89
sphingomyelin measurement
3
84.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enolase 3
VGNC:10211
454457
Mouse
MGI:95395
13808
Rat
RGD:2555
25438
Dog
enolase 3
VGNC:40367
479469
Horse
enolase 3
VGNC:17584
100061187
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enolase 3
Mouse
Rat
Dog
enolase 3
Horse
enolase 3
Publication Statistics
PubMed Score 307.50
PubMed score by year
PubTator Score 53.60
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title