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Tbio
ENO2
Gamma-enolase

Protein Summary
Description
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229277
  • ENSP00000229277
  • ENSG00000111674
  • ENST00000535366
  • ENSP00000437402
  • ENST00000538763
  • ENSP00000441490
  • ENST00000541477
  • ENSP00000438873

Symbol
  • NSE
  • HEL-S-279
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
interacting protein
0.9
hub protein
0.88
small molecule perturbation
0.88
protein domain
0.85


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6270.11   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 1910   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6270.11   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 1910   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (261)
ENO3
Tbio
Family:  Enzyme
Novelty:  0.00322051
p_int:  1
Score:  0.962
Data Source:  BioPlex,STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
p_int:  0.999959942
p_ni:  0.000040058
Score:  0.963
Data Source:  BioPlex,STRINGDB
PGAM1
Tchem
Family:  Enzyme
Novelty:  0.0111272
Score:  0.984
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.981
Data Source:  STRINGDB
PKLR
Tbio
Family:  Kinase
Novelty:  0.00268398
Score:  0.98
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.972
Data Source:  STRINGDB
PGAM2
Tbio
Family:  Enzyme
Novelty:  0.02438933
Score:  0.964
Data Source:  STRINGDB
BPGM
Tbio
Family:  Enzyme
Novelty:  0.03437401
Score:  0.955
Data Source:  STRINGDB
TPI1
Tbio
Family:  Enzyme
Novelty:  0.00074652
Score:  0.955
Data Source:  STRINGDB
PGK1
Tchem
Family:  Kinase
Novelty:  0.00113494
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
oleic acid measurement
2
3
3
95.7
fatty acid measurement
1
2
2
92.8
docosapentaenoic acid measurement
1
2
2
92.8
arachidonic acid measurement
1
2
2
92.8
linolenic acid measurement
1
2
2
92.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
oleic acid measurement
3
95.7
fatty acid measurement
2
92.8
docosapentaenoic acid measurement
2
92.8
arachidonic acid measurement
2
92.8
linolenic acid measurement
2
92.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
enolase 2
714208
Mouse
MGI:95394
13807
Dog
enolase 2
VGNC:40366
100856683
Horse
enolase 2
VGNC:17583
100052776
Cow
enolase 2
VGNC:28497
526006
Species
Name
OMA
EggNOG
Inparanoid
Macaque
enolase 2
Mouse
Dog
enolase 2
Horse
enolase 2
Cow
enolase 2
Publication Statistics
PubMed Score 6270.11
PubMed score by year
PubTator Score 2858.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title