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Tbio
ENO2
Gamma-enolase

Protein Summary
Description
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229277
  • ENSP00000229277
  • ENSG00000111674
  • ENST00000535366
  • ENSP00000437402
  • ENST00000538763
  • ENSP00000441490
  • ENST00000541477
  • ENSP00000438873

Symbol
  • NSE
  • HEL-S-279
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
interacting protein
0.9
hub protein
0.88
small molecule perturbation
0.88
protein domain
0.85


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7071.06   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 1910   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7071.06   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 1910   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0