Protein Summary
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
- ENST00000229277
- ENSP00000229277
- ENSG00000111674
- ENST00000535366
- ENSP00000437402
- ENST00000538763
- ENSP00000441490
- ENST00000541477
- ENSP00000438873
- NSE
- HEL-S-279
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.94 | ||
interacting protein | 0.9 | ||
hub protein | 0.88 | ||
small molecule perturbation | 0.88 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6270.11 (req: < 5)
Gene RIFs: 132 (req: <= 3)
Antibodies: 1910 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6270.11 (req: >= 5)
Gene RIFs: 132 (req: > 3)
Antibodies: 1910 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (261)
ENO1
Family: Enzyme
Novelty: 0.00109178
p_int: 0.999959942
p_ni: 0.000040058
Score: 0.963
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (20)
Reactome (5)
KEGG (6)
PathwayCommons (6)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gluconeogenesis | ||||
Reactome | Glucose metabolism | ||||
Reactome | Glycolysis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gluconeogenesis | ||||
Glucose metabolism | ||||
Glycolysis | ||||
Metabolism | ||||
Metabolism of carbohydrates | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (9)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | CAFA | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
oleic acid measurement | 2 | 3 | 3 | 95.7 | |||||
fatty acid measurement | 1 | 2 | 2 | 92.8 | |||||
docosapentaenoic acid measurement | 1 | 2 | 2 | 92.8 | |||||
arachidonic acid measurement | 1 | 2 | 2 | 92.8 | |||||
linolenic acid measurement | 1 | 2 | 2 | 92.8 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
oleic acid measurement | 3 | 95.7 | |||||
fatty acid measurement | 2 | 92.8 | |||||
docosapentaenoic acid measurement | 2 | 92.8 | |||||
arachidonic acid measurement | 2 | 92.8 | |||||
linolenic acid measurement | 2 | 92.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | enolase 2 | 714208 | ||||||
Mouse | MGI:95394 | 13807 | ||||||
Dog | enolase 2 | VGNC:40366 | 100856683 | |||||
Horse | enolase 2 | VGNC:17583 | 100052776 | |||||
Cow | enolase 2 | VGNC:28497 | 526006 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | enolase 2 | |||||
Mouse | ||||||
Dog | enolase 2 | |||||
Horse | enolase 2 | |||||
Cow | enolase 2 | |||||
Publication Statistics
PubMed Score 6270.11
PubMed score by year
PubTator Score 2858.08
PubTator score by year
Related Publications
Text Mined References (158)
GeneRif Annotations (132)
Items per page:
0 of 0
PMID | Year | Title |
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