Tbio ENDOV Endonuclease V

Protein Summary

Description

Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.

Uniprot Accession IDs

• Q8N8Q3
• I3L3S4
• Q6P2G2
• Q86X99
• Q8NAK0
• hEndoV

Gene Name

• ENDOV

Ensembl ID

• ENST00000323854
• ENSP00000317810
• ENSG00000173818
• ENST00000517795
• ENSP00000461577
• ENST00000518137
• ENSP00000429190
• ENST00000518901
• ENSP00000460685
• ENST00000518907
• ENSP00000458361
• ENST00000520284
• ENSP00000458391
• ENST00000520367
• ENSP00000431036

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
molecular function	0.84
microRNA	0.83
tissue sample	0.67
transcription factor binding site profile	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.75   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.75   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0