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Tbio
ENDOG
Endonuclease G, mitochondrial

Protein Summary
Description
Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity). The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372642
  • ENSP00000361725
  • ENSG00000167136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
kinase perturbation
0.71
transcription factor binding site profile
0.69
histone modification site profile
0.65
chemical
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.28   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.28   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
DNAJA1
Tchem
Novelty:  0.00894126
p_int:  0.999979534
p_ni:  0.000020466
Score:  0.267
Data Source:  BioPlex,STRINGDB
CST5
Tbio
Novelty:  0.04273227
p_int:  0.999954876
p_ni:  0.000040628
p_wrong:  0.000004495
Data Source:  BioPlex
NFYC
Tbio
Family:  TF
Novelty:  0.00626931
p_int:  0.999247385
p_ni:  0.000752615
Data Source:  BioPlex
EVL
Tbio
Novelty:  0.03533257
p_int:  0.9987966
p_ni:  0.001203372
p_wrong:  2.8e-8
Data Source:  BioPlex
ITLN1
Tbio
Novelty:  0.00299735
p_int:  0.998666573
p_ni:  0.001333427
Score:  0.798
Data Source:  BioPlex,STRINGDB
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.997653194
p_ni:  0.00233799
p_wrong:  0.000008816
Data Source:  BioPlex
GRK6
Tchem
Family:  Kinase
Novelty:  0.02740874
p_int:  0.994887467
p_ni:  0.005112533
Score:  0.204
Data Source:  BioPlex,STRINGDB
BAG4
Tbio
Novelty:  0.02660607
p_int:  0.978235481
p_ni:  0.021764517
p_wrong:  2e-9
Score:  0.153
Data Source:  BioPlex,STRINGDB
ITLN2
Tbio
Novelty:  0.15601654
p_int:  0.975229638
p_ni:  0.024770356
p_wrong:  6e-9
Score:  0.874
Data Source:  BioPlex,STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
p_int:  0.953715422
p_ni:  0.046188477
p_wrong:  0.0000961
Score:  0.262
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
83.2
serum gamma-glutamyl transferase measurement
1
1
1
82.6
1
1
0
1.1
56.4
Eczema
1
1
0
1.1
56.4
blood metabolite measurement
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
83.2
serum gamma-glutamyl transferase measurement
1
82.6
0
1.1
56.4
Eczema
0
1.1
56.4
blood metabolite measurement
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endonuclease G
VGNC:13875
742090
Macaque
endonuclease G
717171
Mouse
MGI:1261433
13804
Rat
RGD:1310763
362100
Dog
endonuclease G
VGNC:40360
608916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endonuclease G
Macaque
endonuclease G
Mouse
Rat
Dog
endonuclease G
Publication Statistics
PubMed Score 262.28
PubMed score by year
PubTator Score 134.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title