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Tdark
ENDOD1
Endonuclease domain-containing 1 protein

Protein Summary
Description
May act as a DNase and a RNase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278505
  • ENSP00000278505
  • ENSG00000149218

Symbol
  • KIAA0830
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
0.97
PubMedID
0.86
kinase perturbation
0.66
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.42   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.42   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.999998886
p_ni:  0.000001114
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.999982674
p_ni:  0.000017321
p_wrong:  5e-9
Data Source:  BioPlex
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999916403
p_ni:  0.000083594
p_wrong:  3e-9
Data Source:  BioPlex
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.999801813
p_ni:  0.000198174
p_wrong:  1.3e-8
Data Source:  BioPlex
C20orf141
Tdark
Novelty:  7
p_int:  0.999732467
p_ni:  0.000267359
p_wrong:  1.74e-7
Data Source:  BioPlex
SMPD3
Tchem
Family:  Enzyme
Novelty:  0.01053328
p_int:  0.999632614
p_ni:  0.000367386
Data Source:  BioPlex
CTDSP2
Tbio
Family:  Enzyme
Novelty:  0.01033594
p_int:  0.999610022
p_ni:  0.000389978
Score:  0.196
Data Source:  BioPlex,STRINGDB
SLC34A2
Tchem
Family:  Transporter
Novelty:  0.00601743
p_int:  0.999456225
p_ni:  0.000543774
p_wrong:  1e-9
Score:  0.264
Data Source:  BioPlex,STRINGDB
BZW2
Tbio
Novelty:  0.17006204
p_int:  0.997981729
p_ni:  0.001479141
p_wrong:  0.00053913
Score:  0.207
Data Source:  BioPlex,STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.997782617
p_ni:  0.001993149
p_wrong:  0.000224234
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
96.1
reticulocyte measurement
2
2
2
72.8
reticulocyte count
2
1
2
59
platelet count
1
1
1
48.5
mean reticulocyte volume
1
1
1
41.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
96.1
reticulocyte measurement
2
72.8
reticulocyte count
2
59
platelet count
1
48.5
mean reticulocyte volume
1
41.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919196
71946
Rat
Dog
endonuclease domain containing 1
VGNC:52258
485119
Horse
endonuclease domain containing 1
VGNC:17576
100067528
Cow
endonuclease domain containing 1
VGNC:28490
538618
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
endonuclease domain containing 1
Horse
endonuclease domain containing 1
Cow
endonuclease domain containing 1
Publication Statistics
PubMed Score 3.42
PubMed score by year
PubTator Score 1.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title