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Tbio
ENAM
Enamelin

Protein Summary
Description
Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396073
  • ENSP00000379383
  • ENSG00000132464

Symbol
  • ADAI
  • AI1C
  • AIH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
gene perturbation
0.68
microRNA
0.58
cell line
0.52
biological term
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.9   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.9   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (150)
AMELX
Tbio
Novelty:  0.00063284
Score:  0.995
Data Source:  STRINGDB
AMBN
Tbio
Novelty:  0.00354946
Score:  0.992
Data Source:  STRINGDB
AMTN
Tbio
Novelty:  0.02514528
Score:  0.989
Data Source:  STRINGDB
FAM20C
Tbio
Family:  Enzyme
Novelty:  0.00318966
Score:  0.985
Data Source:  STRINGDB
FAM20A
Tbio
Family:  Enzyme
Novelty:  0.03742119
Score:  0.983
Data Source:  STRINGDB
FBN1
Tbio
Novelty:  0.00074957
Score:  0.961
Data Source:  STRINGDB
MEPE
Tbio
Novelty:  0.00825085
Score:  0.955
Data Source:  STRINGDB
DMP1
Tbio
Novelty:  0.03114505
Score:  0.949
Data Source:  STRINGDB
SPARCL1
Tbio
Novelty:  0.01077806
Score:  0.947
Data Source:  STRINGDB
SPP1
Tbio
Novelty:  0.00014418
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
1
1
14.2
serum metabolite measurement
1
1
1
8.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
14.2
serum metabolite measurement
1
8.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enamelin
VGNC:595
471209
Macaque
enamelin
706750
Mouse
MGI:1333772
13801
Rat
RGD:1306796
289525
Dog
enamelin
VGNC:40358
482186
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enamelin
Macaque
enamelin
Mouse
Rat
Dog
enamelin
Publication Statistics
PubMed Score 166.90
PubMed score by year
PubTator Score 123.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title