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Tbio
EMSY
BRCA2-interacting transcriptional repressor EMSY

Protein Summary
Description
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334736
  • ENSP00000334130
  • ENSG00000158636
  • ENST00000524767
  • ENSP00000433205
  • ENST00000525038
  • ENSP00000436968
  • ENST00000525919
  • ENSP00000432010
  • ENST00000529032
  • ENSP00000432327
  • ENST00000533248
  • ENSP00000433634
  • ENST00000533988
  • ENSP00000434665

Symbol
  • C11orf30
  • GL002
  • C11orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.5   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.5   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0