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Tdark
EML3
Echinoderm microtubule-associated protein-like 3

Protein Summary
Description
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394773
  • ENSP00000378254
  • ENSG00000149499
  • ENST00000494448
  • ENSP00000431752
  • ENST00000529309
  • ENSP00000434513

Symbol
  • ELP95
  • EMAP3
  • EMAP95
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
transcription factor perturbation
0.88
virus perturbation
0.83
protein domain
0.73
tissue sample
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.996575204
p_ni:  0.003424796
Data Source:  BioPlex
DENND6A
Tbio
Novelty:  4.5572617
p_int:  0.996420565
p_ni:  0.003579434
p_wrong:  1e-9
Data Source:  BioPlex
ZAR1L
Tdark
Novelty:  0.08793345
p_int:  0.977193297
p_ni:  0.022806703
Data Source:  BioPlex
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.918959888
p_ni:  0.079714082
p_wrong:  0.00132603
Data Source:  BioPlex
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.877904595
p_ni:  0.119981826
p_wrong:  0.002113579
Score:  0.18
Data Source:  BioPlex,STRINGDB
INSYN2
Tdark
Novelty:  2.55244594
p_int:  0.872790114
p_ni:  0.127209695
p_wrong:  1.92e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
ADCK5
Tdark
Family:  Kinase
Novelty:  1.05895812
Score:  0.722
Data Source:  STRINGDB
SH2D3C
Tbio
Novelty:  0.00356605
Score:  0.688
Data Source:  STRINGDB
LRRN4CL
Tdark
Novelty:  3.27659574
Score:  0.627
Data Source:  STRINGDB
MKLN1
Tbio
Novelty:  0.05014385
Score:  0.574
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
11
12
96
waist-hip ratio
2
7
8
95.6
waist circumference
1
4
4
92.1
BMI-adjusted waist circumference
1
4
4
90.4
forced expiratory volume
2
2
2
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
96
waist-hip ratio
8
95.6
waist circumference
4
92.1
BMI-adjusted waist circumference
4
90.4
forced expiratory volume
2
89.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
echinoderm microtubule associated protein like 3
722262
Mouse
MGI:2387612
225898
Rat
RGD:7630023
102551660
Dog
echinoderm microtubule associated protein like 3
VGNC:40348
483787
Horse
echinoderm microtubule associated protein like 3
VGNC:17566
100063522
Species
Name
OMA
EggNOG
Inparanoid
Macaque
echinoderm microtubule associated protein like 3
Mouse
Rat
Dog
echinoderm microtubule associated protein like 3
Horse
echinoderm microtubule associated protein like 3
Publication Statistics
PubMed Score 3.55
PubMed score by year
PubTator Score 3.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title