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Tbio
EML1
Echinoderm microtubule-associated protein-like 1

Protein Summary
Description
Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262233
  • ENSP00000262233
  • ENSG00000066629
  • ENST00000334192
  • ENSP00000334314

Symbol
  • EMAP1
  • EMAPL
  • EMAPL1
  • BH
  • EMAP
  • ELP79
  • EMAPL
  • HuEMAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
protein domain
0.73
microRNA
0.71
PubMedID
0.68
transcription factor
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.7   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.7   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
FBXO28
Tbio
Novelty:  0.10548865
p_int:  1
Score:  0.263
Data Source:  BioPlex,STRINGDB
TUBB2A
Tclin
Novelty:  0.00902924
p_int:  0.999998922
p_ni:  0.000001078
Score:  0.836
Data Source:  BioPlex,STRINGDB
EML4
Tbio
Novelty:  0.00217772
p_int:  0.999993669
p_ni:  0.000006331
Score:  0.935
Data Source:  BioPlex,STRINGDB
TUBB2B
Tclin
Novelty:  0.02905844
p_int:  0.999949733
p_ni:  0.000050267
Score:  0.704
Data Source:  BioPlex,STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.998123451
p_ni:  0.00176902
p_wrong:  0.000107529
Score:  0.552
Data Source:  BioPlex,STRINGDB
TUBB
Tclin
Novelty:  0.0038007
p_int:  0.986882784
p_ni:  0.013117216
Score:  0.827
Data Source:  BioPlex,STRINGDB
ALK
Tclin
Family:  Kinase
Novelty:  0.00022375
Score:  0.669
Data Source:  STRINGDB
ISG20L2
Tdark
Family:  Enzyme
Novelty:  0.31037114
Score:  0.652
Data Source:  STRINGDB
AIMP1
Tbio
Family:  Enzyme
Novelty:  0.00743447
Score:  0.63
Data Source:  STRINGDB
KIF5A
Tbio
Novelty:  0.01277095
Score:  0.57
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
5
1.1
92
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1.1
92
0
1.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
echinoderm microtubule associated protein like 1
VGNC:3435
453155
Macaque
echinoderm microtubule associated protein like 1
705977
Mouse
MGI:1915769
68519
Rat
RGD:1306374
362783
Dog
echinoderm microtubule associated protein like 1
VGNC:40346
490853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
echinoderm microtubule associated protein like 1
Macaque
echinoderm microtubule associated protein like 1
Mouse
Rat
Dog
echinoderm microtubule associated protein like 1
Publication Statistics
PubMed Score 49.70
PubMed score by year
PubTator Score 44.15
PubTator score by year
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Related Publications
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PMID
Year
Title