Tbio EMILIN2 EMILIN-2

Protein Summary

Description

May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.

Uniprot Accession IDs

• Q9BXX0
• B2RMY3
• Q8NBH3
• Q96JQ4

Gene Name

• EMILIN2

Ensembl ID

• ENST00000254528
• ENSP00000254528
• ENSG00000132205

Symbol

• FOAP-10
• EMILIN-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
cell type or tissue	0.76
PubMedID	0.72
histone modification site profile	0.71
transcription factor perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (26)

Explore Interacting Targets

1 – 10 of 26

• See Interactions on String-DB

NELL2

Tbio

Family:  Enzyme

Novelty:  0.03760438

p_int:  0.999998838

p_ni:  0.000001157

p_wrong:  5e-9

Score:  0.185

Data Source:  BioPlex,STRINGDB

OS9

Tbio

Novelty:  0.01490339

p_int:  0.999976478

p_ni:  0.000023466

p_wrong:  5.7e-8

Data Source:  BioPlex

PLAC9

Tdark

Novelty:  0.23764669

p_int:  0.999190267

p_ni:  0.000809719

p_wrong:  1.4e-8

Data Source:  BioPlex

CCL3L1

Tbio

Novelty:  0.01124082

p_int:  0.999167691

p_ni:  0.000831168

p_wrong:  0.000001141

Data Source:  BioPlex

PCDHGB4

Tdark

Novelty:  0.25018904

p_int:  0.998748427

p_ni:  0.001247986

p_wrong:  0.000003588

Data Source:  BioPlex

NELL1

Tbio

Family:  Enzyme

Novelty:  0.01325888

p_int:  0.998704077

p_ni:  0.001295891

p_wrong:  3.2e-8

Score:  0.173

Data Source:  BioPlex,STRINGDB

MFAP5

Tbio

Novelty:  0.01839035

p_int:  0.99715806

p_ni:  0.002841047

p_wrong:  8.93e-7

Data Source:  BioPlex

DEFA5

Tbio

Novelty:  0.00863727

p_int:  0.994764086

p_ni:  0.001088104

p_wrong:  0.00414781

Data Source:  BioPlex

PCDHB11

Tdark

Novelty:  0.80480462

p_int:  0.992964757

p_ni:  0.007035229

p_wrong:  1.4e-8

Data Source:  BioPlex

RETNLB

Tbio

Novelty:  0.00777842

p_int:  0.984718326

p_ni:  0.015280091

p_wrong:  0.000001583

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (4)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
extracellular matrix constituent conferring elasticity	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	1	2	2		86.7
BMI-adjusted waist-hip ratio	EFO_0007788	3	2	3		86.6
red blood cell distribution width	EFO_0005192	2	2	2		81
mean reticulocyte volume	EFO_0010701	1	1	1		64.4
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		61.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	2		86.7
BMI-adjusted waist-hip ratio	EFO_0007788	3		86.6
red blood cell distribution width	EFO_0005192	2		81
mean reticulocyte volume	EFO_0010701	1		64.4
apolipoprotein A 1 measurement	EFO_0004614	1		61.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell adhesion
Coiled coil
Collagen
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Polymorphism
Reference proteome
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
BMI-adjusted hip circumference
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
hip circumference
mean reticulocyte volume
red blood cell distribution width
reticulocyte measurement
sex hormone-binding globulin measurement
triglyceride measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	elastin microfibril interfacer 2	VGNC:13258	739134
Macaque	elastin microfibril interfacer 2		695758
Mouse	elastin microfibril interfacer 2	MGI:2389136	246707
Rat	elastin microfibril interfacer 2	RGD:1305343	316736
Dog	elastin microfibril interfacer 2	VGNC:40344	100684071

Species	Name	OMA	EggNOG	Inparanoid
Chimp	elastin microfibril interfacer 2
Macaque	elastin microfibril interfacer 2
Mouse	elastin microfibril interfacer 2
Rat	elastin microfibril interfacer 2
Dog	elastin microfibril interfacer 2

Publication Statistics

PubMed Score 3.22

PubMed score by year

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PubTator Score 9.43

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (11)

Items per page:

10

0 of 0

PMID	Year	Title