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Tbio
EMILIN1
EMILIN-1

Protein Summary
Description
May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380320
  • ENSP00000369677
  • ENSG00000138080

Symbol
  • EMI
  • EMI
  • gp115
  • EMILIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.69
tissue sample
0.64
protein domain
0.58
cell type or tissue
0.57
cell line
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.49   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.49   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
TAB2
Tbio
Family:  Enzyme
Novelty:  0.00635786
p_int:  0.99999994
p_ni:  3.7e-8
p_wrong:  2.3e-8
Data Source:  BioPlex
TAB3
Tbio
Family:  Enzyme
Novelty:  0.01768638
p_int:  0.999999929
p_ni:  3.2e-8
p_wrong:  3.9e-8
Score:  0.197
Data Source:  BioPlex,STRINGDB
PPFIA3
Tbio
Novelty:  0.03837299
p_int:  0.999999628
p_ni:  6e-8
p_wrong:  3.12e-7
Data Source:  BioPlex
UBXN1
Tbio
Novelty:  0.10675958
p_int:  0.999999595
p_ni:  4.05e-7
Data Source:  BioPlex
CCDC18
Tdark
Novelty:  0.61246881
p_int:  0.999999543
p_ni:  4.57e-7
Data Source:  BioPlex
TAX1BP1
Tbio
Novelty:  0.02498501
p_int:  0.999999456
p_ni:  5.44e-7
Data Source:  BioPlex
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
p_int:  0.999998764
p_ni:  0.000001236
Score:  0.168
Data Source:  BioPlex,STRINGDB
TAB1
Tchem
Family:  Kinase
Novelty:  0.00721424
p_int:  0.999981858
p_ni:  0.000018142
Data Source:  BioPlex
DDHD2
Tbio
Family:  Enzyme
Novelty:  0.04306798
p_int:  0.999976624
p_ni:  0.000023035
p_wrong:  3.41e-7
Data Source:  BioPlex
METTL15
Tdark
Family:  Enzyme
Novelty:  0.4575663
p_int:  0.999821434
p_ni:  0.000178564
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
8
8
91.9
neutrophil count
1
1
1
63.2
C-reactive protein measurement
2
2
2
61.4
neutrophil percentage of leukocytes
1
1
1
59.1
lymphocyte percentage of leukocytes
1
1
1
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
91.9
neutrophil count
1
63.2
C-reactive protein measurement
2
61.4
neutrophil percentage of leukocytes
1
59.1
lymphocyte percentage of leukocytes
1
57.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elastin microfibril interfacer 1
VGNC:240
459093
Macaque
elastin microfibril interfacer 1
698204
Mouse
MGI:1926189
100952
Rat
RGD:1311209
298845
Dog
elastin microfibril interfacer 1
VGNC:40343
475696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elastin microfibril interfacer 1
Macaque
elastin microfibril interfacer 1
Mouse
Rat
Dog
elastin microfibril interfacer 1
Publication Statistics
PubMed Score 42.49
PubMed score by year
PubTator Score 33.44
PubTator score by year
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Related Publications
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PMID
Year
Title