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Tdark
EMC8
ER membrane protein complex subunit 8

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253457
  • ENSP00000253457
  • ENSG00000131148
  • ENST00000435200
  • ENSP00000391730

Symbol
  • C16orf2
  • C16orf4
  • COX4AL
  • COX4NB
  • FAM158B
  • NOC4
  • NOC4
  • COX4NB
  • C16orf2
  • C16orf4
  • FAM158B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
kinase perturbation
0.84
virus perturbation
0.76
hub protein
0.71
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
EMC6
Tbio
Novelty:  0.18299013
p_int:  0.999983923
p_ni:  0.000016077
Score:  0.997
Data Source:  BioPlex,STRINGDB
EMC2
Tbio
Novelty:  0.05843267
p_int:  0.999970239
p_ni:  0.000029646
p_wrong:  1.15e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
EMC7
Tdark
Novelty:  0.28771768
p_int:  0.999954925
p_ni:  0.000045075
Score:  0.996
Data Source:  BioPlex,STRINGDB
MMGT1
Tdark
Novelty:  0.20333677
p_int:  0.999553264
p_ni:  0.000446736
Score:  0.992
Data Source:  BioPlex,STRINGDB
EMC4
Tbio
Novelty:  0.12174476
p_int:  0.999524207
p_ni:  0.000475793
Score:  0.998
Data Source:  BioPlex,STRINGDB
APOA2
Tbio
Novelty:  0.00117627
p_int:  0.994293388
p_ni:  0.005706612
Data Source:  BioPlex
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.992926899
p_ni:  0.005975267
p_wrong:  0.001097835
Score:  0.65
Data Source:  BioPlex,STRINGDB
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.926259294
p_ni:  0.073589785
p_wrong:  0.000150921
Score:  0.622
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.919134266
p_ni:  0.080862726
p_wrong:  0.000003008
Score:  0.167
Data Source:  BioPlex,STRINGDB
ADCY2
Tbio
Family:  Enzyme
Novelty:  0.01649836
p_int:  0.893731687
p_ni:  0.106179764
p_wrong:  0.000088549
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
4
4
98.3
monocyte percentage of leukocytes
2
4
5
97.7
3
2
0
1.3
80.8
platelet count
2
2
2
80.3
Oral ulcer
1
2
0
1.1
69
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
98.3
monocyte percentage of leukocytes
5
97.7
0
1.3
80.8
platelet count
2
80.3
Oral ulcer
0
1.1
69
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 8
VGNC:5757
741244
Macaque
ER membrane protein complex subunit 8
693674
Mouse
MGI:1343095
18117
Rat
RGD:1311219
361425
Dog
ER membrane protein complex subunit 8
VGNC:40337
479624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 8
Macaque
ER membrane protein complex subunit 8
Mouse
Rat
Dog
ER membrane protein complex subunit 8
Publication Statistics
PubMed Score 3.64
PubMed score by year
PubTator Score 1.14
PubTator score by year
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Related Publications
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PMID
Year
Title