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Tbio
EMC4
ER membrane protein complex subunit 4

Protein Summary
Description
May mediate anti-apoptotic activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249209
  • ENSP00000249209
  • ENSG00000128463
  • ENST00000267750
  • ENSP00000267750

Symbol
  • TMEM85
  • PIG17
  • TMEM85
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
histone modification site profile
0.92
virus perturbation
0.85
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.68   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.68   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
EMC3
Tbio
Novelty:  0.01113829
p_int:  0.999888548
p_ni:  0.000111451
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MMGT1
Tdark
Novelty:  0.20333677
p_int:  0.999753587
p_ni:  0.000246413
Score:  0.995
Data Source:  BioPlex,STRINGDB
EMC8
Tdark
Novelty:  0.2452967
p_int:  0.999524207
p_ni:  0.000475793
Score:  0.998
Data Source:  BioPlex,STRINGDB
EMC9
Tdark
Novelty:  0.52441743
p_int:  0.998352274
p_ni:  0.000165069
p_wrong:  0.001482659
Score:  0.997
Data Source:  BioPlex,STRINGDB
EMC6
Tbio
Novelty:  0.18299013
p_int:  0.997626611
p_ni:  0.002373159
p_wrong:  2.3e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
OR1A2
Tdark
Family:  oGPCR
Novelty:  0.25224717
p_int:  0.9957874
p_ni:  0.00418661
p_wrong:  0.00002599
Data Source:  BioPlex
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.995128085
p_ni:  0.004706921
p_wrong:  0.000164994
Score:  0.669
Data Source:  BioPlex,STRINGDB
EMC2
Tbio
Novelty:  0.05843267
p_int:  0.994784699
p_ni:  0.005196659
p_wrong:  0.000018643
Score:  0.999
Data Source:  BioPlex,STRINGDB
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.992704041
p_ni:  0.007228828
p_wrong:  0.000067131
Score:  0.158
Data Source:  BioPlex,STRINGDB
EMC10
Tbio
Novelty:  0.04986528
p_int:  0.98329928
p_ni:  0.015063557
p_wrong:  0.001637163
Score:  0.968
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 4
VGNC:11862
453300
Macaque
ER membrane protein complex subunit 4
695907
Mouse
MGI:1915282
68032
Rat
RGD:1310905
296049
Dog
ER membrane protein complex subunit 4
VGNC:40334
478241
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 4
Macaque
ER membrane protein complex subunit 4
Mouse
Rat
Dog
ER membrane protein complex subunit 4
Publication Statistics
PubMed Score 10.68
PubMed score by year
PubTator Score 2.50
PubTator score by year
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Related Publications
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PMID
Year
Title