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Tbio
EMC3
ER membrane protein complex subunit 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245046
  • ENSP00000245046
  • ENSG00000125037

Symbol
  • TMEM111
  • POB
  • TMEM111
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.91
disease perturbation
0.9
transcription factor perturbation
0.88
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.39   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.39   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
EMC9
Tdark
Novelty:  0.52441743
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
EMC7
Tdark
Novelty:  0.28771768
p_int:  1
Score:  0.996
Data Source:  BioPlex,STRINGDB
EMC2
Tbio
Novelty:  0.05843267
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EMC6
Tbio
Novelty:  0.18299013
p_int:  0.999986492
p_ni:  0.000013508
Score:  0.989
Data Source:  BioPlex,STRINGDB
EMC4
Tbio
Novelty:  0.12174476
p_int:  0.999888548
p_ni:  0.000111451
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
EMC10
Tbio
Novelty:  0.04986528
p_int:  0.999853412
p_ni:  0.000146396
p_wrong:  1.93e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
PLAC9
Tdark
Novelty:  0.23764669
p_int:  0.999150168
p_ni:  0.000849832
p_wrong:  1e-9
Data Source:  BioPlex
EMC1
Tbio
Novelty:  0.05360812
p_int:  0.998748046
p_ni:  0.001251954
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.996524045
p_ni:  0.003475955
Score:  0.666
Data Source:  BioPlex,STRINGDB
MMGT1
Tdark
Novelty:  0.20333677
p_int:  0.994164752
p_ni:  0.005835243
p_wrong:  6e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
40.6
body mass index
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
40.6
body mass index
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 3
VGNC:11389
460162
Macaque
ER membrane protein complex subunit 3
699481
Mouse
MGI:1913337
66087
Rat
RGD:1311566
312640
Dog
ER membrane protein complex subunit 3
VGNC:40333
476537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 3
Macaque
ER membrane protein complex subunit 3
Mouse
Rat
Dog
ER membrane protein complex subunit 3
Publication Statistics
PubMed Score 97.39
PubMed score by year
PubTator Score 28.20
PubTator score by year
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Related Publications
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PMID
Year
Title