You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EMC10
ER membrane protein complex subunit 10

Protein Summary
Description
Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334976
  • ENSP00000334037
  • ENSG00000161671
  • ENST00000376918
  • ENSP00000366117

Symbol
  • C19orf63
  • HSM1
  • INM02
  • HSM1
  • HSS1
  • C19orf63
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.68
virus perturbation
0.64
transcription factor
0.63
disease perturbation
0.62
transcription factor binding site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.97   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.97   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
EMC9
Tdark
Novelty:  0.52441743
p_int:  0.999891768
p_ni:  0.000108231
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
EMC3
Tbio
Novelty:  0.01113829
p_int:  0.999853412
p_ni:  0.000146396
p_wrong:  1.93e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
EMC6
Tbio
Novelty:  0.18299013
p_int:  0.999334382
p_ni:  0.000665617
p_wrong:  1e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
EMC7
Tdark
Novelty:  0.28771768
p_int:  0.998966362
p_ni:  0.001033007
p_wrong:  6.31e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
EMC2
Tbio
Novelty:  0.05843267
p_int:  0.998384283
p_ni:  0.001615001
p_wrong:  7.16e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.992461658
p_ni:  0.007310503
p_wrong:  0.00022784
Score:  0.719
Data Source:  BioPlex,STRINGDB
MMGT1
Tdark
Novelty:  0.20333677
p_int:  0.990639876
p_ni:  0.009359988
p_wrong:  1.36e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
SDF2L1
Tbio
Novelty:  0.12184663
p_int:  0.988992725
p_ni:  0.007173808
p_wrong:  0.003833467
Score:  0.238
Data Source:  BioPlex,STRINGDB
EMC4
Tbio
Novelty:  0.12174476
p_int:  0.98329928
p_ni:  0.015063557
p_wrong:  0.001637163
Score:  0.968
Data Source:  BioPlex,STRINGDB
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.983191241
p_ni:  0.015197027
p_wrong:  0.001611733
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
Name
Explore in Pharos
Explore in Source
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
1
1
0
1.4
73
2
1
0
1.4
58.4
electrocardiography
1
1
1
14.2
hematocrit
1
1
1
12.9
hemoglobin measurement
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
0
1.4
73
0
1.4
58.4
electrocardiography
1
14.2
hematocrit
1
12.9
hemoglobin measurement
1
11.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 10
VGNC:11007
748504
Macaque
ER membrane protein complex subunit 10
719285
Mouse
MGI:1916933
69683
Rat
RGD:1303214
292878
Dog
ER membrane protein complex subunit 10
VGNC:40332
484362
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 10
Macaque
ER membrane protein complex subunit 10
Mouse
Rat
Dog
ER membrane protein complex subunit 10
Publication Statistics
PubMed Score 21.97
PubMed score by year
PubTator Score 8.63
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title