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Tbio
EMB
Embigin

Protein Summary
Description
Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303221
  • ENSP00000302289
  • ENSG00000170571
  • ENST00000514111
  • ENSP00000426404

Symbol
  • GP70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
virus perturbation
0.94
kinase
0.85
PubMedID
0.82
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.25   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.25   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
SLC16A11
Tbio
Family:  Transporter
Novelty:  0.07860306
p_int:  0.999994912
p_ni:  0.000005087
p_wrong:  1e-9
Score:  0.398
Data Source:  BioPlex,STRINGDB
IL20
Tbio
Novelty:  0.78184288
p_int:  0.999459694
p_ni:  0.000536659
p_wrong:  0.000003646
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.99795564
p_ni:  0.002041252
p_wrong:  0.000003107
Score:  0.171
Data Source:  BioPlex,STRINGDB
FNDC11
Tdark
Novelty:  20.00979352
p_int:  0.997547356
p_ni:  0.002450325
p_wrong:  0.000002319
Score:  0.228
Data Source:  BioPlex,STRINGDB
LPCAT2
Tbio
Family:  Enzyme
Novelty:  0.02794035
p_int:  0.997380445
p_ni:  0.002512242
p_wrong:  0.000107313
Data Source:  BioPlex
HSD17B1
Tchem
Family:  Enzyme
Novelty:  0.00313425
p_int:  0.997334253
p_ni:  0.002489045
p_wrong:  0.000176702
Data Source:  BioPlex
DHRS9
Tbio
Family:  Enzyme
Novelty:  0.00256743
p_int:  0.997145736
p_ni:  0.002849958
p_wrong:  0.000004306
Score:  0.163
Data Source:  BioPlex,STRINGDB
OS9
Tbio
Novelty:  0.01490339
p_int:  0.996756746
p_ni:  0.003142908
p_wrong:  0.000100347
Score:  0.152
Data Source:  BioPlex,STRINGDB
RCL1
Tbio
Family:  Enzyme
Novelty:  0.02116964
p_int:  0.996172835
p_ni:  0.000876021
p_wrong:  0.002951144
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.995872191
p_ni:  0.004110958
p_wrong:  0.000016851
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Proton-coupled monocarboxylate transport (R-HSA-433692)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Proton-coupled monocarboxylate transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Proton-coupled monocarboxylate transport
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
embigin
VGNC:3977
461886
Macaque
embigin
702068
Mouse
MGI:95321
13723
Rat
RGD:621067
114511
Dog
embigin
VGNC:50876
479340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
embigin
Macaque
embigin
Mouse
Rat
Dog
embigin
Publication Statistics
PubMed Score 773.25
PubMed score by year
PubTator Score 299.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title