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Tbio
ELP5
Elongator complex protein 5

Protein Summary
Description
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354429
  • ENSP00000346412
  • ENSG00000170291
  • ENST00000356683
  • ENSP00000349111
  • ENST00000396627
  • ENSP00000379868
  • ENST00000396628
  • ENSP00000379869
  • ENST00000573657
  • ENSP00000459633
  • ENST00000574255
  • ENSP00000461489
  • ENST00000574993
  • ENSP00000459835

Symbol
  • C17orf81
  • DERP6
  • DERP6
  • MST071
  • HSPC002
  • MSTP071
  • C17orf81
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
transcription factor
0.76
transcription factor perturbation
0.74
histone modification site profile
0.71
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.8   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.8   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0