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Tbio
ELP5
Elongator complex protein 5

Protein Summary
Description
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354429
  • ENSP00000346412
  • ENSG00000170291
  • ENST00000356683
  • ENSP00000349111
  • ENST00000396627
  • ENSP00000379868
  • ENST00000396628
  • ENSP00000379869
  • ENST00000573657
  • ENSP00000459633
  • ENST00000574255
  • ENSP00000461489
  • ENST00000574993
  • ENSP00000459835

Symbol
  • C17orf81
  • DERP6
  • DERP6
  • MST071
  • HSPC002
  • MSTP071
  • C17orf81
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
transcription factor
0.76
transcription factor perturbation
0.74
histone modification site profile
0.71
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
ELP6
Tbio
Novelty:  0.01229878
p_int:  0.999999964
p_ni:  8e-9
p_wrong:  2.8e-8
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
p_int:  0.999998123
p_ni:  2.39e-7
p_wrong:  0.000001638
Score:  0.857
Data Source:  BioPlex,STRINGDB
ELP3
Tbio
Family:  Epigenetic
Novelty:  0.0166061
p_int:  0.999865946
p_ni:  0.000036313
p_wrong:  0.000097741
Score:  0.97
Data Source:  BioPlex,Reactome,STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.999579672
p_ni:  0.000012928
p_wrong:  0.0004074
Score:  0.795
Data Source:  BioPlex,STRINGDB
ELP4
Tbio
Novelty:  0.03734233
p_int:  0.996907857
p_ni:  0.000005999
p_wrong:  0.003086144
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
ELP2
Tbio
Novelty:  0.03034629
Score:  0.965
Data Source:  Reactome,STRINGDB
ELP1
Tbio
Novelty:  0.0035777
Score:  0.935
Data Source:  Reactome,STRINGDB
VPS25
Tbio
Novelty:  0.03002488
Score:  0.71
Data Source:  STRINGDB
ZNF835
Tdark
Family:  TF
Novelty:  2.91666667
Score:  0.551
Data Source:  STRINGDB
DPH2
Tbio
Novelty:  0.04268301
Score:  0.475
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
7
6
15.8
99.5
apolipoprotein B measurement
2
5
6
97.6
low density lipoprotein cholesterol measurement
7
5
12
97.1
total cholesterol measurement
4
4
8
95.8
birth weight
4
3
4
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
6
15.8
99.5
apolipoprotein B measurement
6
97.6
low density lipoprotein cholesterol measurement
12
97.1
total cholesterol measurement
8
95.8
birth weight
4
89.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongator complex protein 5
455799
Macaque
elongator acetyltransferase complex subunit 5
721799
Mouse
MGI:1859017
54351
Rat
RGD:1303303
287446
Dog
elongator acetyltransferase complex subunit 5
VGNC:40329
479480
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongator complex protein 5
Macaque
elongator acetyltransferase complex subunit 5
Mouse
Rat
Dog
elongator acetyltransferase complex subunit 5
Publication Statistics
PubMed Score 14.82
PubMed score by year
PubTator Score 3.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title