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Tbio
ELP3
Elongator complex protein 3

Protein Summary
Description
Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed:19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256398
  • ENSP00000256398
  • ENSG00000134014
  • ENST00000380353
  • ENSP00000369711
  • ENST00000521015
  • ENSP00000428449
  • ENST00000537665
  • ENSP00000445558

Symbol
  • KAT9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
molecular function
0.95
disease perturbation
0.93
transcription factor perturbation
0.91
virus perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.91   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.91   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (206)
ZFYVE16
Tbio
Novelty:  0.10765234
p_int:  0.999993956
p_ni:  0.000006041
p_wrong:  3e-9
Data Source:  BioPlex
ELP2
Tbio
Novelty:  0.03034629
p_int:  0.999986375
p_ni:  0.000013625
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ELP4
Tbio
Novelty:  0.03734233
p_int:  0.999983564
p_ni:  0.000016436
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ELP1
Tbio
Novelty:  0.0035777
p_int:  0.999949746
p_ni:  0.000050255
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ELP5
Tbio
Novelty:  0.07212185
p_int:  0.999865946
p_ni:  0.000036313
p_wrong:  0.000097741
Score:  0.97
Data Source:  BioPlex,Reactome,STRINGDB
MPG
Tchem
Family:  Enzyme
Novelty:  0.00373538
p_int:  0.999853921
p_ni:  0.000146079
Score:  0.209
Data Source:  BioPlex,STRINGDB
SIRT3
Tchem
Family:  Epigenetic
Novelty:  0.00101187
p_int:  0.997855531
p_ni:  0.002134415
p_wrong:  0.000010054
Score:  0.455
Data Source:  BioPlex,STRINGDB
FAM219B
Tdark
Novelty:  5.26378794
p_int:  0.997545432
p_ni:  0.002454568
Score:  0.228
Data Source:  BioPlex,STRINGDB
KPTN
Tbio
Novelty:  0.06841936
p_int:  0.996522377
p_ni:  0.003477623
Data Source:  BioPlex
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.996071945
p_ni:  0.003928055
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
5
5
87.2
eosinophil count
1
1
1
62.1
2
1
1
1.1
50
body height
1
1
1
21.2
comparative body size at age 10, self-reported
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
87.2
eosinophil count
1
62.1
1
1.1
50
body height
1
21.2
comparative body size at age 10, self-reported
1
10.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongator acetyltransferase complex subunit 3
VGNC:883
464081
Macaque
elongator acetyltransferase complex subunit 3
713512
Mouse
MGI:1921445
74195
Rat
RGD:2324506
100362548
Dog
elongator acetyltransferase complex subunit 3
VGNC:40328
477370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongator acetyltransferase complex subunit 3
Macaque
elongator acetyltransferase complex subunit 3
Mouse
Rat
Dog
elongator acetyltransferase complex subunit 3
Publication Statistics
PubMed Score 69.91
PubMed score by year
PubTator Score 24.92
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title