Tchem ELOVL6 Elongation of very long chain fatty acids protein 6

Protein Summary

Description

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9H5J4
• Q4W5L0
• Q8NCD1

Gene Name

• ELOVL6

Ensembl ID

• ENST00000302274
• ENSP00000304736
• ENSG00000170522
• ENST00000394607
• ENSP00000378105

Symbol

• FACE
• LCE
• FAE
• LCE
• FACE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
PubMedID	0.96
transcription factor binding site profile	0.89
kinase perturbation	0.84
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Elongation Of Very Long Chain Fatty Acids Protein 6

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Elongation Of Very Long Chain Fatty Acids Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.43   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.43   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 77

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0