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Tchem
ELOVL6
Elongation of very long chain fatty acids protein 6

Protein Summary
Description
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302274
  • ENSP00000304736
  • ENSG00000170522
  • ENST00000394607
  • ENSP00000378105

Symbol
  • FACE
  • LCE
  • FAE
  • LCE
  • FACE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
PubMedID
0.96
transcription factor binding site profile
0.89
kinase perturbation
0.84
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.43   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.43   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 77
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (94)
HSD17B12
Tbio
Family:  Enzyme
Novelty:  0.02200219
Score:  0.96
Data Source:  STRINGDB
SREBF2
Tchem
Family:  TF
Novelty:  0.00171709
Score:  0.951
Data Source:  STRINGDB
ACSL1
Tchem
Family:  Enzyme
Novelty:  0.00336161
Score:  0.95
Data Source:  STRINGDB
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
Score:  0.947
Data Source:  STRINGDB
ACSL5
Tchem
Family:  Enzyme
Novelty:  0.00850919
Score:  0.944
Data Source:  STRINGDB
ACSL3
Tbio
Family:  Enzyme
Novelty:  0.01772336
Score:  0.937
Data Source:  STRINGDB
ACSBG2
Tbio
Family:  Enzyme
Novelty:  0.1072938
Score:  0.932
Data Source:  STRINGDB
ACSL4
Tbio
Family:  Enzyme
Novelty:  0.0072645
Score:  0.915
Data Source:  STRINGDB
ACSBG1
Tbio
Family:  Enzyme
Novelty:  0.00381436
Score:  0.915
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.839
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
6
5
4.6
98.6
epidermal growth factor measurement
2
2
2
93.2
platelet crit
1
2
2
82.4
mean corpuscular volume
2
2
2
81.4
monocyte count
4
4
4
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
4.6
98.6
epidermal growth factor measurement
2
93.2
platelet crit
2
82.4
mean corpuscular volume
2
81.4
monocyte count
4
80.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELOVL fatty acid elongase 6
VGNC:596
461436
Mouse
MGI:2156528
170439
Rat
RGD:620585
171402
Dog
ELOVL fatty acid elongase 6
VGNC:40324
487900
Horse
ELOVL fatty acid elongase 6
VGNC:17542
100072829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELOVL fatty acid elongase 6
Mouse
Rat
Dog
ELOVL fatty acid elongase 6
Horse
ELOVL fatty acid elongase 6
Publication Statistics
PubMed Score 176.43
PubMed score by year
PubTator Score 81.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title