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Tbio
ELOVL5
Elongation of very long chain fatty acids protein 5

Protein Summary
Description
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304434
  • ENSP00000306640
  • ENSG00000012660
  • ENST00000370913
  • ENSP00000359951
  • ENST00000370918
  • ENSP00000359956

Symbol
  • ELOVL2
  • HELO1
  • SCA38
  • dJ483K16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor perturbation
0.96
disease perturbation
0.95
transcription factor binding site profile
0.87
small molecule perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.99   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.99   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.989964691
p_ni:  0.010019711
p_wrong:  0.000015598
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.986261832
p_ni:  0.005908086
p_wrong:  0.007830081
Data Source:  BioPlex
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.97058576
p_ni:  0.006232448
p_wrong:  0.023181792
Score:  0.161
Data Source:  BioPlex,STRINGDB
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.964096453
p_ni:  0.000444538
p_wrong:  0.035459008
Score:  0.158
Data Source:  BioPlex,STRINGDB
FADS2
Tbio
Family:  Enzyme
Novelty:  0.00180901
Score:  0.986
Data Source:  STRINGDB
HSD17B12
Tbio
Family:  Enzyme
Novelty:  0.02200219
Score:  0.966
Data Source:  STRINGDB
FADS1
Tchem
Family:  Enzyme
Novelty:  0.00160193
Score:  0.831
Data Source:  STRINGDB
ELOVL2
Tbio
Novelty:  0.00665823
Score:  0.808
Data Source:  STRINGDB
FADS3
Tbio
Family:  Enzyme
Novelty:  0.02899077
Score:  0.779
Data Source:  STRINGDB
SCD
Tchem
Family:  Enzyme
Novelty:  0.00063325
Score:  0.773
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Linoleic acid (LA) metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Linoleic acid (LA) metabolism
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
78.2
lymphocyte count
2
1
2
72.5
mean reticulocyte volume
1
1
1
39.6
survival time
1
1
0
1.8
36.9
metastasis measurement
1
1
0
1.8
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
78.2
lymphocyte count
2
72.5
mean reticulocyte volume
1
39.6
survival time
0
1.8
36.9
metastasis measurement
0
1.8
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ELOVL fatty acid elongase 5
712243
Mouse
MGI:1916051
68801
Rat
RGD:620583
171400
Dog
ELOVL fatty acid elongase 5
VGNC:40323
610377
Horse
ELOVL fatty acid elongase 5
VGNC:17541
100069400
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ELOVL fatty acid elongase 5
Mouse
Rat
Dog
ELOVL fatty acid elongase 5
Horse
ELOVL fatty acid elongase 5
Publication Statistics
PubMed Score 207.99
PubMed score by year
PubTator Score 27.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title