Tbio ELOVL1 Elongation of very long chain fatty acids protein 1

Protein Summary

Description

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.

Uniprot Accession IDs

• Q9BW60
• B4DP24
• Q53HT2
• Q5JUY3
• Q8WXU3
• Q9NVD9
• Q9Y396

Gene Name

• ELOVL1

Ensembl ID

• ENST00000372458
• ENSP00000361536
• ENSG00000066322
• ENST00000413844
• ENSP00000416024
• ENST00000621943
• ENSP00000477602

Symbol

• SSC1
• Ssc1
• CGI-88

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
disease perturbation	0.95
transcription factor binding site profile	0.69
histone modification site profile	0.67
transcription factor	0.65

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Elongation Of Very Long Chain Fatty Acids Protein 1

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Elongation Of Very Long Chain Fatty Acids Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.89   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.89   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0