Tbio ELOC Elongin-C

Protein Summary

Description

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q15369
• E5RGD9
• Q567Q6
• EloC

Gene Name

• ELOC

Ensembl ID

• ENST00000284811
• ENSP00000284811
• ENSG00000154582
• ENST00000518127
• ENSP00000428334
• ENST00000519487
• ENSP00000429596
• ENST00000520210
• ENSP00000430224
• ENST00000520242
• ENSP00000428171
• ENST00000522337
• ENSP00000429906
• ENST00000523815
• ENSP00000428074
• ENST00000622804
• ENSP00000478121

Symbol

• TCEB1
• SIII
• TCEB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Elongin-c

DTO Classes

Protein / Enzyme Modulator / Elongin-c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.38   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 229   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.38   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (517)

Explore Interacting Targets

1 – 10 of 517

• See Interactions on String-DB

ASB9

Tbio

Novelty:  0.18287435

p_int:  0.999340186

p_ni:  0.000659814

Score:  0.995

Data Source:  BioPlex,STRINGDB

VHL

Tchem

Family:  Enzyme

Novelty:  0.00285782

p_int:  0.999126815

p_ni:  0.000873185

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ANKRD9

Tdark

Novelty:  0.43181793

p_int:  0.997528493

p_ni:  0.002471507

Score:  0.907

Data Source:  BioPlex,STRINGDB

NRBP1

Tbio

Family:  Kinase

Novelty:  0.05902656

p_int:  0.993633975

p_ni:  0.006366025

Score:  0.474

Data Source:  BioPlex,STRINGDB

RAB40B

Tbio

Novelty:  0.2288213

p_int:  0.990959475

p_ni:  0.009040525

Score:  0.891

Data Source:  BioPlex,STRINGDB

KLHDC2

Tbio

Novelty:  0.01485159

p_int:  0.990606725

p_ni:  0.009393275

Score:  0.323

Data Source:  BioPlex,STRINGDB

ASB6

Tdark

Novelty:  0.32074223

p_int:  0.973498175

p_ni:  0.026501825

Score:  0.947

Data Source:  BioPlex,STRINGDB

ELOA2

Tdark

Family:  Enzyme

Novelty:  0.7420148

p_int:  0.966450944

p_ni:  0.033549056

Score:  0.991

Data Source:  BioPlex,Reactome,STRINGDB

RAB40A

Tbio

Novelty:  0.12112671

p_int:  0.931934262

p_ni:  0.068065738

Score:  0.889

Data Source:  BioPlex,STRINGDB

ASB3

Tbio

Novelty:  0.15921018

p_int:  0.912802143

p_ni:  0.087197857

Score:  0.601

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (48)

Reactome (39)

KEGG (5)

PathwayCommons (2)

WikiPathways (2)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cellular response to hypoxia	76 targets	R-HSA-1234174
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Axon guidance	533 targets	R-HSA-422475
Cellular response to hypoxia	76 targets	R-HSA-1234174
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Components (3)

Processes (9)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
elongin complex	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytosol	Traceable Author Statement (TAS)	Reactome
nucleoplasm	Traceable Author Statement (TAS)	Reactome

Disease Associations ()

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		47.7
alkaline phosphatase measurement	EFO_0004533	1	1	1		45.7
total cholesterol measurement	EFO_0004574	1	1	1		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	1		47.7
alkaline phosphatase measurement	EFO_0004533	1		45.7
total cholesterol measurement	EFO_0004574	1		30.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Host-virus interaction
Nucleus
Reference proteome
Transcription
Transcription regulation
Ubl conjugation pathway

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
low density lipoprotein cholesterol measurement
total cholesterol measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	elongin C		698922
Mouse	elongin C	MGI:1915173	67923
Rat	elongin C	RGD:620658	64525
Dog	elongin C	VGNC:40317	477914
Horse	elongin C	VGNC:17536	100060902

Species	Name	OMA	EggNOG	Inparanoid
Macaque	elongin C
Mouse	elongin C
Rat	elongin C
Dog	elongin C
Horse	elongin C

Publication Statistics

PubMed Score 84.38

PubMed score by year

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PubTator Score 53.03

PubTator score by year

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Related Publications

Text Mined References (70)

GeneRif Annotations (20)

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PMID	Year	Title