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Tbio
ELL3
RNA polymerase II elongation factor ELL3

Protein Summary
Description
Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex requi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319359
  • ENSP00000320346
  • ENSG00000128886
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
histone modification site profile
0.75
kinase perturbation
0.71
transcription factor binding site profile
0.61
cell type or tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.66   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.66   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  1
Score:  0.932
Data Source:  BioPlex,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
p_int:  1
Score:  0.74
Data Source:  BioPlex,STRINGDB
MLLT1
Tchem
Novelty:  0.00328241
p_int:  0.999999931
p_ni:  6.9e-8
p_wrong:  1e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
ICE1
Tbio
Novelty:  0.0208695
p_int:  0.999999839
p_ni:  1.27e-7
p_wrong:  3.5e-8
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
AFF1
Tbio
Family:  TF
Novelty:  0.00094358
p_int:  0.99999933
p_ni:  9e-9
p_wrong:  6.6e-7
Score:  0.92
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999998673
p_ni:  0.000001324
p_wrong:  2e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.999996364
p_ni:  0.000003636
p_wrong:  1e-9
Score:  0.948
Data Source:  BioPlex,Reactome,STRINGDB
MLLT3
Tchem
Novelty:  0.00361056
p_int:  0.999984043
p_ni:  0.000015957
Score:  0.812
Data Source:  BioPlex,STRINGDB
CCNT1
Tchem
Novelty:  0.00526848
p_int:  0.999971526
p_ni:  0.000028472
p_wrong:  1e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
CDK14
Tchem
Family:  Kinase
Novelty:  0.02074169
p_int:  0.999954382
p_ni:  0.000045618
Score:  0.186
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
2
3
95.2
sex hormone-binding globulin measurement
6
1
6
87.8
platelet crit
1
1
1
85.9
platelet count
1
1
1
85.4
mean corpuscular hemoglobin concentration
1
1
1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
95.2
sex hormone-binding globulin measurement
6
87.8
platelet crit
1
85.9
platelet count
1
85.4
mean corpuscular hemoglobin concentration
1
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongation factor for RNA polymerase II 3
VGNC:10168
742758
Macaque
elongation factor for RNA polymerase II 3
711271
Mouse
MGI:2673679
269344
Rat
RGD:1309917
296102
Dog
elongation factor for RNA polymerase II 3
VGNC:40308
487526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongation factor for RNA polymerase II 3
Macaque
elongation factor for RNA polymerase II 3
Mouse
Rat
Dog
elongation factor for RNA polymerase II 3
Publication Statistics
PubMed Score 8.66
PubMed score by year
PubTator Score 4.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title