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Tbio
ELL2
RNA polymerase II elongation factor ELL2

Protein Summary
Description
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237853
  • ENSP00000237853
  • ENSG00000118985

Symbol
  • MRCCAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
transcription factor perturbation
0.91
gene perturbation
0.88
PubMedID
0.88
microRNA
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.48   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.48   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.999999998
p_ni:  1e-9
p_wrong:  1e-9
Score:  0.97
Data Source:  BioPlex,STRINGDB
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  0.999999783
p_ni:  2.17e-7
Score:  0.996
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999903113
p_ni:  0.000086429
p_wrong:  0.000010459
Score:  0.665
Data Source:  BioPlex,STRINGDB
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
Score:  0.973
Data Source:  STRINGDB
CCNT1
Tchem
Novelty:  0.00526848
Score:  0.968
Data Source:  STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.947
Data Source:  STRINGDB
CCNT2
Tbio
Novelty:  0.04593314
Score:  0.941
Data Source:  STRINGDB
SUPT4H1
Tbio
Novelty:  0.0127914
Score:  0.927
Data Source:  STRINGDB
ELL3
Tbio
Family:  Enzyme
Novelty:  0.18245631
Score:  0.927
Data Source:  STRINGDB
GTF2F2
Tbio
Novelty:  0.02446629
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
14
95.9
reticulocyte measurement
3
2
6
89.4
serum non-albumin protein measurement
2
2
2
78.3
albumin:globulin ratio measurement
1
1
1
59.6
1
1
0
1.2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
14
95.9
reticulocyte measurement
6
89.4
serum non-albumin protein measurement
2
78.3
albumin:globulin ratio measurement
1
59.6
0
1.2
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongation factor for RNA polymerase II 2
VGNC:6861
461741
Macaque
elongation factor for RNA polymerase II 2
699506
Mouse
MGI:2183438
192657
Rat
RGD:1309296
309918
Dog
elongation factor for RNA polymerase II 2
VGNC:40307
488899
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongation factor for RNA polymerase II 2
Macaque
elongation factor for RNA polymerase II 2
Mouse
Rat
Dog
elongation factor for RNA polymerase II 2
Publication Statistics
PubMed Score 30.48
PubMed score by year
PubTator Score 15.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title